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B2417

苯扎咪 盐酸盐 水合物

≥98% (HPLC), ENaC and NCX inhibitor, solid

别名:

N-（苄基脒）-3,5-二氨基-6-氯吡嗪甲酰胺 盐酸盐 水合物

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关于此项目

经验公式（希尔记法）:
C13H14ClN7O · HCl · xH2O
化学文摘社编号:
161804-20-2
分子量:
356.21 (anhydrous basis)
MDL number:
MFCD28147597
UNSPSC Code:
12352200
PubChem Substance ID:
24278262
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
desiccated
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产品名称

苯扎咪 盐酸盐 水合物, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

yellow

solubility

methanol: 10 mg/mL, DMSO: >20 mg/mL

storage temp.

2-8°C

SMILES string

O.Cl.Nc1nc(N)c(nc1Cl)C(=O)NC(=N)NCc2ccccc2

InChI

1S/C13H14ClN7O.ClH.H2O/c14-9-11(16)20-10(15)8(19-9)12(22)21-13(17)18-6-7-4-2-1-3-5-7;;/h1-5H,6H2,(H4,15,16,20)(H3,17,18,21,22);1H;1H2

InChI key

YAJQRPFIYXRNKS-UHFFFAOYSA-N

Gene Information

human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340)
mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768)

Biochem/physiol Actions

Na + /H + 和 Na + /Ca 2 + 通道的选择性和强效阻断剂

Features and Benefits

该化合物是受体分类及信号转导手册上酸感应（质子门控）离子通道 (ASIC)页面上的特色化合物。想要浏览手册的其他页面， 请单击此处。

Other Notes

阿米洛利的 Nω-苄基衍生物。

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
066M4614V
015M4605V
073M4620V
059K46102V
059K4610V

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J W Lane et al.
British journal of pharmacology, 106(2), 283-286 (1992-06-11)
1. Patch clamp recording techniques have been used to compare the block caused by amiloride and some of its structural analogues of the mechanosensitive (MS) cation selective channel in frog (Xenopus laevis) oocytes. 2. Like amiloride, the amiloride analogues dimethylamiloride
A Catalina Vélez-Ortega et al.
eLife, 6 (2017-03-30)
Mechanotransducer channels at the tips of sensory stereocilia of inner ear hair cells are gated by the tension of 'tip links' interconnecting stereocilia. To ensure maximal sensitivity, tip links are tensioned at rest, resulting in a continuous influx of Ca2+
G N Pierce et al.
The Journal of pharmacology and experimental therapeutics, 265(3), 1280-1291 (1993-06-01)
Amiloride and its derivatives (benzamil, dichlorobenzamil, 5-(N,N-dimethyl)-amiloride, 5-(N-ethyl-N-isopropyl)-amiloride, (N,N-hexamethylene)- amiloride and 5-(N-methyl-N-isobutyl)-amiloride) are commonly used as selective blockers of Na+/Ca++ exchange or Na+/H+ exchange. Very little information is currently available regarding their effects on cardiac performance. It was observed that
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全球贸易项目编号

货号GTIN
B2417-50MG04061832569246
B2417-10MG04061833426777