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B2515

L-丁硫氨酸亚砜亚胺

Name: <SC>L</SC>-丁硫氨酸亚砜亚胺
Brand: SIGMA

synthetic (organic), ≥97% (TLC), γ-glutamylcysteine synthetase inhibitor, powder

别名:

L-BSO

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关于此项目

经验公式（希尔记法）:

C₈H₁₈N₂O₃S

化学文摘社编号:

83730-53-4

分子量:

222.31

NACRES:

NA.77

PubChem Substance ID:

24278263

UNSPSC Code:

12352202

MDL number:

MFCD00067000

Beilstein/REAXYS Number:

2367136

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属性

产品名称

L-丁硫氨酸亚砜亚胺, ≥97% (TLC)

biological source

synthetic (organic)

Quality Level

200

assay

≥97% (TLC)

form

powder

mp

224-226 °C

solubility

water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

shipped in

wet ice

storage temp.

−20°C

SMILES string

CCCCS(=N)(=O)CC[C@H](N)C(O)=O

InChI

1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1

InChI key

KJQFBVYMGADDTQ-CVSPRKDYSA-N

Gene Information

human ... GCLC(2729), GCLM(2730)

说明

Application

L丁硫氨酸-亚砜亚胺已用作：

选择性激活剂，以诱导大鼠凋亡细胞的铁死亡
γ谷氨酰半胱氨酸合成酶抑制剂，以研究其对小黑麦和大麦小孢子胚胎发生（ME）诱导活力和效果的影响
谷胱甘肽合成阻断剂，以研究其在小鼠肺泡巨噬细胞中金诺芬（AFN）介导的白介素-1β表达的影响

用于诱导实验性谷胱甘肽缺乏，以研究谷胱甘肽在细胞过程中的作用。

Biochem/physiol Actions

通过抑制谷胱甘肽生物合成中的关键酶γ-谷氨酰半胱氨酸合成酶，进而阻断对化疗的细胞抵抗性。用于诱导实验性谷胱甘肽缺乏，以研究谷胱甘肽在细胞过程中的作用。

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

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Hilaire C Lam et al.

Cancer research, 77(12), 3255-3267 (2017-05-18)

p62/sequestosome-1 (SQSTM1) is a multifunctional adaptor protein and autophagic substrate that accumulates in cells with hyperactive mTORC1, such as kidney cells with mutations in the tumor suppressor genes tuberous sclerosis complex (TSC)1 or TSC2. Here we report that p62 is

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