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B3306

Bisindolylmaleimide IV

≥98% (TLC), solid

别名:

Ro 31-6233

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关于此项目

经验公式（希尔记法）:
C20H13N3O2
化学文摘社编号:
119139-23-0
分子量:
327.34
NACRES:
NA.77
PubChem Substance ID:
24891709
UNSPSC Code:
12352111
MDL number:
MFCD00236432
Assay:
≥98% (TLC)
Form:
solid
Quality level:
200
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biological source

synthetic (organic)

Quality Level

200

assay

≥98% (TLC)

form

solid

color

dark red

solubility

DMSO: soluble, methanol: soluble

storage temp.

−20°C

SMILES string

O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c4c[nH]c5ccccc45

InChI

1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)

InChI key

DQYBRTASHMYDJG-UHFFFAOYSA-N

Gene Information

human ... CDK2(1017), EGFR(1956)
rat ... Prkca(24680)

Biochem/physiol Actions

Bisindolylmaleimides (BIM) comprises a group of 11 compounds from BIM-I to BIM-XI. BIMs act as an inhibitor of protein kinase C (PKC). They are derived from staurosporine. BIM IX due to its proapoptotic functionality could be useful in targeting tumor proliferation.

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLCC4079
SLBX1783
SLBV4162
SLBR5786V
SLBP3755V

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Gérard Prulière et al.
Molecular biology of the cell, 22(12), 2042-2053 (2011-04-22)
The atypical protein kinase C (aPKC) is part of the conserved aPKC/PAR6/PAR3 protein complex, which regulates many cell polarity events, including the formation of a primary cilium at the apical surface of epithelial cells. Cilia are highly organized, conserved, microtubule-based
Hui He et al.
The Prostate, 70(10), 1119-1126 (2010-03-25)
We have reported that human prostate cancer ARCaP(E) cells undertake epithelial to mesenchymal transition (EMT) when stimulated by certain soluble factors, and that EMT is regulated by surface receptor-elicited signaling pathways through protein phosphorylation. It is known that phorbol ester
Nihar R Jena
Journal of molecular modeling, 18(2), 631-644 (2011-05-12)
Binding of several bisindolylmaleimide (BIS) like (BIS-3, BIS-8 and UCN1) and other ligands (H89, SB203580 and Y27632) with the glycogen synthase kinase-3 (GSK-3β) has been studied using combined docking, molecular dynamics and Poisson-Boltzmann surface area analysis approaches. The study generated
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全球贸易项目编号

货号GTIN
B3306-1MG04061833427651
B3306-5MG04061833427668