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B5435

BIA 2-093

Name: BIA 2-093
Brand: SIGMA

≥98% (HPLC), solid

别名:

S-(−)-10-Acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide

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关于此项目

经验公式（希尔记法）:

C₁₇H₁₆N₂O₃

化学文摘社编号:

236395-14-5

分子量:

296.32

NACRES:

NA.77

PubChem Substance ID:

24891837

UNSPSC Code:

12352200

MDL number:

MFCD06798333

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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属性

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: ~21 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

CC(=O)O[C@H]1Cc2ccccc2N(C(N)=O)c3ccccc13

InChI

1S/C17H16N2O3/c1-11(20)22-16-10-12-6-2-4-8-14(12)19(17(18)21)15-9-5-3-7-13(15)16/h2-9,16H,10H2,1H3,(H2,18,21)/t16-/m0/s1

InChI key

QIALRBLEEWJACW-INIZCTEOSA-N

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
rat ... Scnn1g(24768)

说明

Biochem/physiol Actions

Blocker of voltage-gated sodium channels; significantly blocks excitatory amino acid (glutamate and aspartate) release.

Blocks voltage-gated sodium channels and excitatory amino acid release.

pictograms

GHS07

signalword

Warning

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

法规信息

新产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

064K4629

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Interaction of the novel anticonvulsant, BIA 2-093, with voltage-gated sodium channels: comparison with carbamazepine.

M J Bonifácio et al.

Epilepsia, 42(5), 600-608 (2001-05-31)

BIA 2-093 [(S)-(-)-10-acetoxy-10,11-dihydro-5H-dibenz/b,f/azepine-5-carboxamide] is endowed with an anticonvulsant potency similar to that of carbamazepine (CBZ), but produces less cognitive and motor impairment. This study evaluated whether voltage-gated sodium channels (VGSCs) are a primary locus for the action of BIA 2-093.

The novel anticonvulsant BIA 2-093 inhibits transmitter release during opening of voltage-gated sodium channels: a comparison with carbamazepine and oxcarbazepine.

António Parada et al.

Neurochemistry international, 40(5), 435-440 (2002-02-01)

(S)-(-)-10-acetoxy-10,11-dihydro-5H-dibenz/b,f/azepine-5-carboxamide (BIA 2-093) is endowed with high anticonvulsant activity and shares with carbamazepine (CBZ) and oxcarbazepine (OXC) the capability to inhibit voltage-gated sodium channels (VGSC). The present study was aimed to compare the effects of BIA 2-093, CBZ and OXC

全球贸易项目编号

货号	GTIN
B5435-10MG	04061832555515