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B8299

N-Butyldeoxynojirimycin

Name: N-Butyldeoxynojirimycin
Brand: SIGMA

film (dried in situ), ≥98% (TLC)

别名:

Miglustat, NB-DNJ

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关于此项目

经验公式（希尔记法）:

C₁₀H₂₁NO₄

化学文摘社编号:

72599-27-0

分子量:

219.28

UNSPSC Code:

12352200

PubChem Substance ID:

24892070

NACRES:

NA.32

MDL number:

MFCD00272581

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属性

产品名称

N-Butyldeoxynojirimycin, film (dried in situ)

assay

≥98% (TLC)

Quality Level

200

form

film (dried in situ)

solubility

water: 9.80-10.20 mg/mL, clear, colorless

storage temp.

2-8°C

SMILES string

CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO

InChI

1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1

InChI key

UQRORFVVSGFNRO-UTINFBMNSA-N

Gene Information

human ... UGCG(7357)

说明

General description

N-Butyldeoxynojirimycin is an alkylated product of imino sugar deoxynojirimycin.

Application

N-Butyldeoxynojirimycin has been used:

in the inhibition of glycolipid synthesis in neuroblastoma cells
in the inhibition the ceramide-specific glycosyltransferase in hepatocytes
in the inhibition of β-glucosidase (GBA2) using fluorescence- activity assay in human embryonic kidney (HEK293) cells.

Biochem/physiol Actions

N-Butyldeoxynojirimycin is an inhibitor of glucosyltransferase and α-glucosidases. N-Butyldeoxynojirimycin, also known as misglustat, reduces glycolipid levels by substrate reduction therapy (SRT) and is effectively used for the treatment of glycosphingolipid lysosomal storage disorder, Gaucher disease.

α-glucosidase Inhibitor

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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A multicenter, open-label, phase III study of Abcertin in Gaucher disease.

Beom Hee Lee et al.

Medicine, 96(45), e8492-e8492 (2017-11-16)

Gaucher disease (GD) is caused by a deficiency in the lysosomal enzyme glucocerebrosidase. Enzyme replacement therapy (ERT) is recommended for clinical improvement. The efficacy and safety of a new imiglucerase, Abcertin, were assessed in 7 Egyptian patients with treatment-naïve type

Cytoskeletal inhibitors, anti-adhesion molecule antibodies, and lectins inhibit hepatocyte spheroid formation

Nakamura M, et al.

Acta Medica Okayama, 56(1), 43-50 (2002)

The role of the iminosugar N-butyldeoxynojirimycin (miglustat) in the management of type I (non-neuronopathic) Gaucher disease: a position statement

Cox TM, et al.

Journal of inherited metabolic disease, 26(6), 513-526 (2003)

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全球贸易项目编号

货号	GTIN
B8299-1MG	04061826740996
B8299-5MG	04061833627846