B9385
Boc-Val-Pro-Arg-7-酰胺基-4-甲基香豆素 盐酸盐
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关于此项目
经验公式（希尔记法）:
C31H45N7O7
化学文摘社编号:
分子量:
627.73
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352204
MDL number:
assay
≥98% (TLC)
Quality Level
form
powder
solubility
water: 20 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
Cl.CC(C)C(NC(=O)OC(C)(C)C)C(=O)N1CCCC1C(=O)NC(CCCNC(N)=N)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2
InChI
1S/C31H45N7O7.ClH/c1-17(2)25(37-30(43)45-31(4,5)6)28(42)38-14-8-10-22(38)27(41)36-21(9-7-13-34-29(32)33)26(40)35-19-11-12-20-18(3)15-24(39)44-23(20)16-19;/h11-12,15-17,21-22,25H,7-10,13-14H2,1-6H3,(H,35,40)(H,36,41)(H,37,43)(H4,32,33,34);1H
InChI key
ROQGJTZGLVLVIN-UHFFFAOYSA-N
General description
Boc-Val-Pro-Arg-AMC用作人类激肽释放素8的合成底物。
一种用于凝血酶的荧光底物。
Application
Boc-Val-Pro-Arg-7-氨基-4-甲基香豆素盐酸盐已被用于
- 在唾液蛋白cE5抑制试验中作为凝血酶的荧光底物
- 作为凝血酶荧光底物的重组E. nipponicum丝氨酸蛋白酶抑制剂抑制试验
- 作为血淋巴蛋白蛋白酶测定的底物
Packaging
无底玻璃瓶。内含物装在锥底内插管中。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
实验方案
凝血酶是一种内溶性丝氨酸蛋白酶，可选择性裂解纤维蛋白原的精氨酸-甘氨酸键，从而形成纤维蛋白并释放纤维蛋白肽A和B。
Thrombin is an endolytic serine protease that selectively cleaves the Arg–Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.
Tadaaki Kishi et al.
Biological chemistry, 387(6), 723-731 (2006-06-28)
Human kallikrein 8 (hK8), whose gene was originally cloned as the human ortholog of a mouse brain protease, is known to be associated with diseases such as ovarian cancer and Alzheimer's disease. Recombinant human pro-kallikrein 8 was activated with lysyl
Luciano Pirone et al.
The Journal of biological chemistry, 292(30), 12632-12642 (2017-06-09)
Saliva of blood-feeding arthropods carries several antihemostatic compounds whose physiological role is to facilitate successful acquisition of blood. The identification of novel natural anticoagulants and the understanding of their mechanism of action may offer opportunities for designing new antithrombotics disrupting
T Morita et al.
Journal of biochemistry, 82(5), 1495-1498 (1977-11-01)
Twenty peptide-4-methylcoumarin amides (MCA) were newly synthesized and tested as possible substrates for alpha-thrombin, factor Xa, kallikreins, urokinase, and plasmin. These fluorogenic peptides contained arginine-MCA as the carboxyl-terminus. Release of 7-amino-4-methylcoumarin was determined fluorometrically. Of these peptides, the following were
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| B9385-5MG | 04061833443736 |