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B9636

S-苯甲酰硫胺 O-单磷酸

Name: S-苯甲酰硫胺 O-单磷酸
Brand: SIGMA

别名:

苯磷硫胺

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关于此项目

经验公式（希尔记法）:

C₁₉H₂₃N₄O₆PS

化学文摘社编号:

22457-89-2

分子量:

466.45

NACRES:

NA.79

PubChem Substance ID:

24892147

UNSPSC Code:

12352116

EC Number:

245-013-4

MDL number:

MFCD00057343

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属性

assay

≥98% (TLC)

Quality Level

200

form

powder or crystals

color

white to off-white

storage temp.

2-8°C

SMILES string

Cc1ncc(CN(C=O)\C(C)=C(/CCOP(O)(O)=O)SC(=O)c2ccccc2)c(N)n1

InChI

1S/C19H23N4O6PS/c1-13(23(12-24)11-16-10-21-14(2)22-18(16)20)17(8-9-29-30(26,27)28)31-19(25)15-6-4-3-5-7-15/h3-7,10,12H,8-9,11H2,1-2H3,(H2,20,21,22)(H2,26,27,28)/b17-13+

InChI key

BTNNPSLJPBRMLZ-GHRIWEEISA-N

说明

General description

S-苯甲酰基硫胺 O-单磷酸酯（苯磷硫胺）是两亲性 S-酰基硫胺衍生物。是一种脂溶性维生素。苯磷硫胺含噻唑环。与硫胺素相比，苯磷硫胺具有更高的生物利用度。

Application

S-苯甲酰基硫胺 O-单磷酸酯用于确定其对大鼠骨骼肌缺血和再灌注的影响。

Biochem/physiol Actions

S-苯甲酰基硫胺 O-单磷酸酯（苯磷硫胺）是一种治疗剂。有助于预防视网膜病变、神经病变和肾脏病变等糖尿病并发症。苯磷硫胺抑制糖尿病患者糖基化终末产物（AGE）的合成。苯磷硫胺被认为是预防糖尿病神经病变的营养保健产品。

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

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Protective role of benfotiamine, a fat-soluble vitamin B1 analogue, in lipopolysaccharide-induced cytotoxic signals in murine macrophages.

Umesh C S Yadav et al.

Free radical biology & medicine, 48(10), 1423-1434 (2010-03-12)

This study was designed to investigate the molecular mechanisms by which benfotiamine, a lipid-soluble analogue of vitamin B1, affects lipopolysaccharide (LPS)-induced inflammatory signals leading to cytotoxicity in the mouse macrophage cell line RAW264.7. Benfotiamine prevented LPS-induced apoptosis, expression of the

Liver, plasma and erythrocyte levels of thiamine and its phosphate esters in rats with acute ethanol intoxication: a comparison of thiamine and benfotiamine administration.

Guilherme Vannucchi Portari et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(4-5), 799-802 (2013-02-02)

Thiamine and benfotiamine are vitamin B1 and pro-vitamin B1 substances, respectively. Vitamin B1 plays an essential role in energy metabolism, and its deficiency leads to neurologic and cardiovascular pathologies, as seen in alcoholics. This study presents new data about the

The multifaceted therapeutic potential of benfotiamine

Balakumar P, et al.

Pharmacological Research, 61(6), 482-488 (2010)

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全球贸易项目编号

货号	GTIN
B9636-250MG	04061833443866