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C0884

辅酶 B₁₂

Name: 辅酶 B<SUB>12</SUB>
Brand: SIGMA

≥97.0%

别名:

5′-脱氧腺苷, DMBC辅酶, 腺苷钴胺, 腺苷钴胺素

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关于此项目

经验公式（希尔记法）:

C₇₂H₁₀₀CoN₁₈O₁₇P

化学文摘社编号:

13870-90-1

分子量:

1579.58

UNSPSC Code:

12352205

NACRES:

NA.79

PubChem Substance ID:

24892282

EC Number:

237-627-6

Beilstein/REAXYS Number:

4122932

MDL number:

MFCD00135609

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属性

Quality Level

100

assay

≥97.0%

form

powder and chunks

technique(s)

HPLC: suitable

color

red to very dark red, very dark red-brown

storage temp.

−20°C

SMILES string

CC(CNC(=O)CCC1(C)C(CC(N)=O)C2N([Co+]C[C@H]3O[C@@H]([C@H](O)[C@@H]3O)n4cnc5c(N)ncnc45)C1=C(C)C6=NC(=CC7=NC(=C(C)C8=NC2(C)C(C)(CC(N)=O)C8CCC(N)=O)C(C)(CC(N)=O)C7CCC(N)=O)C(C)(C)C6CCC(N)=O)OP([O-])(=O)O[C@H]9[C@@H](O)[C@H](O[C@@H]9CO)n%10cnc%11cc(C)c(C)cc%10%11

InChI

1S/C62H90N13O14P.C10H12N5O3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);2-4,6-7,10,16-17H,1H2,(H2,11,12,13);/q;;+2/p-2/t31?,34?,35?,36?,37?,41-,52-,53-,56?,57+,59?,60?,61?,62?;4-,6-,7-,10+;/m11./s1

InChI key

ZIHHMGTYZOSFRC-PMDPKNCCSA-L

说明

General description

维生素B₁₂ （钴胺素）是指一组化学上相关的含钴分子。维生素B₁₂的生理活性形式包括甲钴胺和腺苷钴胺素，而羟钴胺素（维生素_12a，OHCb1）和氰钴胺素（CNCb1）是其储存和递送的形式。

Application

在yvrC-lacZ 融合的体内检测中，辅酶 B₁₂可用作质粒变种培养的增补剂。

Biochem/physiol Actions

维生素B₁₂（钴胺素）参与DNA合成和脂肪酸合成。作为一种辅酶，它也在线粒体甲基丙二酰基辅酶A转化为琥珀酰辅酶A的过程中起关键作用。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Cobalamin (coenzyme B12): synthesis and biological significance.

J R Roth et al.

Annual review of microbiology, 50, 137-181 (1996-01-01)

This review examines deoxyadenosylcobalamin (Ado-B12) biosynthesis, transport, use, and uneven distribution among living forms. We describe how genetic analysis of enteric bacteria has contributed to these issues. Two pathways for corrin ring formation have been found-an aerobic pathway (in P.

Large-scale domain conformational change is coupled to the activation of the Co-C bond in the B12-dependent enzyme ornithine 4,5-aminomutase: a computational study.

Jiayun Pang et al.

Journal of the American Chemical Society, 134(4), 2367-2377 (2012-01-14)

We present here an energetic and atomistic description of how D-ornithine 4,5-aminomutase (OAM), an adenosylcobalamin (AdoCbl; coenzyme B(12))-dependent isomerase, employs a large-scale protein domain conformational change to orchestrate the homolytic rupture of the Co-C bond. Our results suggest that in

Radical catalysis in coenzyme B12-dependent isomerization (eliminating) reactions.

Tetsuo Toraya

Chemical reviews, 103(6), 2095-2127 (2003-06-12)

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全球贸易项目编号

货号	GTIN
C0884-100MG	04061833269428
C0884-1G	04061833452394
C0884-250MG	04061833452400
C0884-25MG	04061833452424

主要文件

辅酶 B₁₂

≥97.0%

选择尺寸

关于此项目

Quality Level

assay

form

technique(s)

color

storage temp.

SMILES string

InChI

InChI key

General description

Application

Biochem/physiol Actions

安全信息

存储类别

wgk

flash_point_f

flash_point_c

ppe

文件

分析证书(COA)

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全球贸易项目编号

主要文件

辅酶 B12

≥97.0%

选择尺寸

关于此项目

Quality Level

assay

form

technique(s)

color

storage temp.

SMILES string

InChI

InChI key

General description

Application

Biochem/physiol Actions

安全信息

存储类别

wgk

flash_point_f

flash_point_c

ppe

文件

分析证书(COA)

已有该产品？

同行评审论文

全球贸易项目编号

辅酶 B₁₂