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Merck
CN

C104

(±)-CPP

solid

别名:

(±)-3-(2-羧基哌嗪-4-基)丙基-1-膦酸

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关于此项目

经验公式(希尔记法):
C8H17N2O5P
化学文摘社编号:
分子量:
252.20
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
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form

solid

Quality Level

color

white

solubility

H2O: 99.2 mg/mL, ethanol: insoluble

SMILES string

OC(=O)C1CN(CCCP(O)(O)=O)CCN1

InChI

1S/C8H17N2O5P/c11-8(12)7-6-10(4-2-9-7)3-1-5-16(13,14)15/h7,9H,1-6H2,(H,11,12)(H2,13,14,15)

InChI key

CUVGUPIVTLGRGI-UHFFFAOYSA-N

Application

(±)-CPP可用作非竞争性NMDA受体拮抗剂:
  • 研究其对小鼠血糖的影响作用
  • 用于小鼠大脑切片的电生理记录
  • 用于大鼠海马体锥体神经元的电生理记录

Biochem/physiol Actions

4-(3-膦酰丙基)哌嗪-2-羧酸(CPP)是强效、竞争性和选择性的N-甲基-D-天冬氨酸(NMDA)受体拮抗剂。它是2-氨基-7-膦酰庚酸的类似物。CPP具有抗惊厥和镇痛作用。

Disclaimer

吸湿


pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Thien-Tri Cung et al.
The New England journal of medicine, 373(11), 1021-1031 (2015-09-01)
Experimental and clinical evidence suggests that cyclosporine may attenuate reperfusion injury and reduce myocardial infarct size. We aimed to test whether cyclosporine would improve clinical outcomes and prevent adverse left ventricular remodeling. In a multicenter, double-blind, randomized trial, we assigned
Mohammadali Foroozandeh et al.
Magnetic resonance in chemistry : MRC, 53(11), 894-900 (2015-08-21)
Resolution enhancement is a long-sought goal in NMR spectroscopy. In conventional multidimensional NMR experiments, such as the (1) H-(13) C HSQC, the resolution in the indirect dimensions is typically 100 times lower as in 1D spectra because it is limited
Anita E Autry et al.
Nature, 475(7354), 91-95 (2011-06-17)
Clinical studies consistently demonstrate that a single sub-psychomimetic dose of ketamine, an ionotropic glutamatergic NMDAR (N-methyl-D-aspartate receptor) antagonist, produces fast-acting antidepressant responses in patients suffering from major depressive disorder, although the underlying mechanism is unclear. Depressed patients report the alleviation



全球贸易项目编号

货号GTIN
C104-5MG04061833006085
C104-100MG04061833006061
C104-25MG04061833006078