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C1230

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone

Name: Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone
Brand: SIGMA

≥90% (TLC), powder

别名:

Z-IETD-FMK

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关于此项目

经验公式（希尔记法）:

C₃₀H₄₃FN₄O₁₁

化学文摘社编号:

220760-26-9

分子量:

654.68

NACRES:

NA.77

PubChem Substance ID:

329774744

UNSPSC Code:

12352209

MDL number:

MFCD01861686

Assay:

≥90% (TLC)

Form:

powder

Quality level:

200

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属性

biological source

synthetic (organic)

Quality Level

200

assay

≥90% (TLC)

form

powder

solubility

methanol: 10 mg/mL, DMSO: 20 mM, clear, colorless to light yellow

shipped in

dry ice

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CC(O)=O)C(=O)CF

InChI

1S/C28H39FN4O11/c1-4-15(2)23(33-28(43)44-14-17-8-6-5-7-9-17)26(41)30-18(10-11-21(36)37)25(40)32-24(16(3)34)27(42)31-19(12-22(38)39)20(35)13-29/h5-9,15-16,18-19,23-24,34H,4,10-14H2,1-3H3,(H,30,41)(H,31,42)(H,32,40)(H,33,43)(H,36,37)(H,38,39)/t15-,16+,18-,19-,23-,24-/m0/s1

InChI key

CTXDBLYOEUERAT-VUVYEONESA-N

说明

Application

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) has been used as a caspase-8 inhibitor:

to study the activity of caspase-8 in porcine kidney cells
to study its effects on porcine parvovirus (PPV)-induced caspase-3 activity in steroidogenic luteal cells
to study its effects on retinal ganglion and astroglia in rat eyes

Biochem/physiol Actions

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) is an irreversible and cell-permeable caspase-8 inhibitor.

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

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全球贸易项目编号

货号	GTIN
C1230-1MG	04061833461952