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Merck
CN

C127

CNQX

≥98% (HPLC), AMPA/kainate glutamate receptor antagonist, solid

别名:

6-氰基-7-硝基喹喔啉-2,3-二酮, FG-9065

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关于此项目

经验公式(希尔记法):
C9H4N4O4
化学文摘社编号:
分子量:
232.15
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
Storage condition:
protect from light
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产品名称

CNQX, ≥98% (HPLC), solid

Quality Level

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

yellow

solubility

DMSO: >10 mg/mL, H2O: insoluble

SMILES string

[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1C#N

InChI

1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)

InChI key

RPXVIAFEQBNEAX-UHFFFAOYSA-N

Application

CNQX已用于:
  • 作为α-氨基-3-羟基-5-甲基-4-异噁唑丙酸(AMPA)/红藻氨酸阻断剂,研究其对胚胎多能干细胞(pESC)丝状伪足(cytoneme)形成的影响
  • 作为谷氨酸阻断剂,降低触角叶中心神经元电流钳记录中的突触输入
  • 作为非N-甲基-D-天冬氨酸(NMDA)受体阻断剂,研究其对大鼠心率的影响作用

Biochem/physiol Actions

有效的竞争性AMPA/红藻氨酸谷氨酸受体拮抗剂。


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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Guan Hock Khoo et al.
Molecular neurobiology, 56(9), 6436-6450 (2019-03-04)
Long-term depression (LTD) of synaptic efficacy is widely regarded as a cellular basis of learning and memory. The magnitude of hippocampal CA1 LTD induced by low-frequency stimulation (LFS) declines with age, but the mechanisms involved remain poorly understood. Perineuronal nets
Ira Espuny-Camacho et al.
Neuron, 77(3), 440-456 (2013-02-12)
The study of human cortical development has major implications for brain evolution and diseases but has remained elusive due to paucity of experimental models. Here we found that human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), cultured
Emmanuelle Berret et al.
Nature communications, 8(1), 557-557 (2017-09-17)
Oligodendrocyte (OL) maturation and axon-glial communication are required for proper myelination in the developing brain. However, physiological properties of OLs remain largely uncharacterized in different brain regions. The roles of oligodendroglial voltage-activated Na+ channels (Nav) and electrical excitability in relation



全球贸易项目编号

货号GTIN
C127-50MG04061833467251
C127-25MG04061833467244
C127-5MG04061832089621