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C130

氯-APB 氢溴酸盐

solid

别名:

(±)-6-氯-7,8-二羟基-3-烯丙基-1-苯基-2,3,4,5-四氢-1H-3-苯并氮杂卓 氢溴酸盐, (±)-SKF-82958 氢溴酸盐, 6-氯-N-烯丙基-SKF-38393 氢溴酸盐

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关于此项目

经验公式（希尔记法）:
C19H20ClNO2 · HBr
化学文摘社编号:
80751-65-1
分子量:
410.73
NACRES:
NA.77
PubChem Substance ID:
24277890
UNSPSC Code:
12352200
MDL number:
MFCD00069235
Form:
solid
Quality level:
100
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form

solid

Quality Level

100

color

tan

solubility

H2O: 3.7 mg/mL, aqueous base: unstable, ethanol: soluble

storage temp.

2-8°C

SMILES string

Br.Oc1cc2C(CN(CCc2c(Cl)c1O)CC=C)c3ccccc3

InChI

1S/C19H20ClNO2.BrH/c1-2-9-21-10-8-14-15(11-17(22)19(23)18(14)20)16(12-21)13-6-4-3-5-7-13;/h2-7,11,16,22-23H,1,8-10,12H2;1H

InChI key

WLXGFAVTAAQOFH-UHFFFAOYSA-N

Gene Information

human ... DRD1(1812)

Application

氯-APB氢溴酸盐用于药理学刺激D1多巴胺受体，研究其对小鼠脂肪量和肥胖相关蛋白(FTO)缺陷多巴胺D1受体表达的中刺状神经元(D1 MSN)运动反应的影响。

Biochem/physiol Actions

氯-APB氢溴酸盐又名SKF 82958，是一种D1多巴胺受体激动剂。D1受体激动剂预防和逆转芬太尼诱导的呼吸抑制，而不损害猫的阿片类镇痛作用。

Disclaimer

光敏性

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
075M4609V
128H4606
087H4660

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Kenneth D Carr et al.
Psychopharmacology, 202(4), 731-743 (2008-10-09)
Previous studies have suggested that chronic food restriction (FR) increases sensitivity of a neural substrate for drug reward. The neuroanatomical site(s) of key neuroadaptations may include nucleus accumbens (NAc) where changes in D-1 dopamine (DA) receptor-mediated cell signaling and gene
Elena H Chartoff et al.
Psychopharmacology, 204(2), 227-239 (2009-01-17)
Chronic opiate administration induces neuroadaptations within the nucleus accumbens (NAc) and ventral tegmental area (VTA) that can contribute to dependence. We have shown that morphine dependence shifts the behavioral consequences of D1 dopamine (DA) receptor signaling: systemic administration of a
Thomas P Giordano et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(50), 17051-17062 (2010-12-17)
L-type Ca(2+) channel (LTCC)-activated signaling cascades contribute significantly to psychostimulant-induced locomotor sensitization; however, the precise contribution of the two brain-specific subunits Ca(v)1.2 and Ca(v)1.3 remains mostly unknown. In this study, by using amphetamine and cocaine locomotor sensitization in mutant mice
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