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C1530

Cyclopiazonic acid

Name: Cyclopiazonic acid
Brand: SIGMA

from Penicillium cyclopium, ≥98% (HPLC), powder, sarcoplasmic reticulum Ca²⁺-pump inhibitor

别名:

CPA

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关于此项目

经验公式（希尔记法）:

C₂₀H₂₀N₂O₃

化学文摘社编号:

18172-33-3

分子量:

336.38

UNSPSC Code:

12352106

PubChem Substance ID:

24892420

NACRES:

NA.77

MDL number:

MFCD00167445

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

200

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属性

产品名称

环盐酸吗甲吡嗪酸来源于圆弧青霉菌, ≥98% (HPLC), powder

Quality Level

200

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: soluble, chloroform: soluble

storage temp.

−20°C

SMILES string

CN1C(=O)C(=C(\C)O)\C(=O)C2C(Cc3cccc4[nH]cc2c34)C1(C)C

InChI

1S/C20H22N2O3/c1-10(23)15-18(24)17-12-9-21-14-7-5-6-11(16(12)14)8-13(17)20(2,3)22(4)19(15)25/h5-7,9,13,17,21,23H,8H2,1-4H3/b15-10-

InChI key

WJCPGKDPOYBOOJ-GDNBJRDFSA-N

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA3(140)
mouse ... Adora1(11539)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)

说明

General description

圆弧偶氮酸（CPA）是由多种曲霉和 青霉菌 种合成的tetramic酸。

Application

圆弧青霉菌来源圆弧偶氮酸用于：

作为标准品，用于薄层色谱法（TLC）检测和定量黄曲霉毒素
作为培养基成分，用于不含Ca²⁺的DMEM（含10％胎牛血清（FBS））
作为肌质网/内质网Ca²⁺ -ATP酶的可逆抑制剂，检测腔内钙在内质网（ER）-至-高尔基体转运过程中的作用
作为内质网Ca²⁺-ATP酶的阻滞剂，处理神经元；研究内质网（ER）在Ca²⁺诱导的Ca²⁺ 释放（CICR）抑制 SERCA 过程中，对释放和维持Ca²⁺ 的影响

Biochem/physiol Actions

抑制肌质网 Ca ^{2 +}-泵。

pictograms

GHS06

signalword

Danger

hcodes

H300

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 2 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Plant and fungal toxins as contaminants of feed and meat

Improving the Safety of Fresh Meat, 77-101 (2005)

Cyclopiazonic acid depletes intracellular Ca2+ stores and activates an influx pathway for divalent cations in HL-60 cells.

N Demaurex et al.

The Journal of biological chemistry, 267(4), 2318-2324 (1992-02-05)

The filling state of intracellular Ca2+ stores has been proposed to regulate Ca2+ influx across the plasma membrane in a variety of tissues. To test this hypothesis, we have used three structurally unrelated inhibitors of the Ca(2+)-ATPase of intracellular Ca2+

cAMP-Dependent Calcium Oscillations of Astrocytes: An Implication for Pathology.

Sakiko Ujita et al.

Cerebral cortex (New York, N.Y. : 1991), 27(2), 1602-1614 (2016-01-24)

Astrocytes in various brain regions exhibit spontaneous intracellular calcium elevations both in vitro and in vivo; however, neither the temporal pattern underlying this activity nor its function has been fully evaluated. Here, we utilized a long-term optical imaging technique to

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全球贸易项目编号

货号	GTIN
C1530-10MG	04061833467701
C1530-50MG	04061833269510
C1530-5MG	04061833467718