Anti-Calcium Channel (α_1D Subunit) (L-type of Voltage-gated Ca²⁺ Channel) antibody produced in rabbit

synthetic peptide corresponding to amino acids 859-875 of rat α_1D (Accession P27732). This epitope is highly conserved in human and hamster.

Anti-Calcium Channel (α1D Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit is suitable for the following applications:

• immunocytochemistry at a dilution of 1:30-1:150
• immunoprecipitation
• western blot (chemiluminescent) at a dilution of 1:100-1:200

Ca_v1.3 also known as the calcium channel, voltage-dependent, L type, α1D subunit (CACNA1D), is a human gene. It responds more sensitively to depolarization than those of Ca_v1.2 or Ca_v3.1. Ca_v1.3 is required for proper hearing as well as sinoatrial node and brain function. It undergoes extensive alternative splicing. Alternative splicing in the C terminus and drastically modifies gating properties of the channel. The L-type calcium channel Ca_v1.3 is important in human glucose-induced insulin secretion and common variants in CACNA1D may contribute to type 2 diabetes.

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.05% sodium azide

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