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C1768

Cytarabine

Name: Cytarabine
Brand: SIGMA

≥90% (HPLC), crystalline, DNA replication inhibitor

别名:

(β-D-阿拉伯呋喃糖基)胞嘧啶, Ara-C, 胞嘧啶阿拉伯糖苷, 阿拉伯糖胞嘧啶, 阿糖胞嘧啶, 阿糖胞苷

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关于此项目

经验公式（希尔记法）:

C₉H₁₃N₃O₅

化学文摘社编号:

147-94-4

分子量:

243.22

NACRES:

NA.77

PubChem Substance ID:

24892435

UNSPSC Code:

12352200

EC Number:

205-705-9

MDL number:

MFCD00066487

Beilstein/REAXYS Number:

89175

Assay:

≥90% (HPLC)

Form:

crystalline

Quality level:

200

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属性

产品名称

胞嘧啶 β-D-呋喃阿拉伯糖苷, crystalline, ≥90% (HPLC)

Quality Level

200

assay

≥90% (HPLC)

form

crystalline

storage temp.

2-8°C

SMILES string

NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O

InChI

1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1

InChI key

UHDGCWIWMRVCDJ-CCXZUQQUSA-N

Gene Information

human ... POLA1(5422), POLA2(23649), POLB(5423), POLD1(5424), POLD2(5425), POLD3(10714), POLD4(57804), POLE(5426), POLE2(5427), POLE3(54107), PRIM1(5557), PRIM2(5558)
mouse ... Cda(72269)

说明

Biochem/physiol Actions

阿糖胞苷复合到 DNA 中后，可通过与导致 DNA 断裂的拓扑异构酶 I 形成可裂解复合物而抑制 DNA 的复制，但不会抑制 RNA 的合成。抗白血病制剂。

Features and Benefits

该化合物是细胞凋亡研究的特色产品。点击此处，查看更多细胞凋亡精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。

Still not finding the right product?

Explore all of our products under 胞嘧啶 β-D-呋喃阿拉伯糖苷

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

pictograms

GHS08

signalword

Danger

hcodes

H340,H361fd

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Muta. 1B - Repr. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

DNA损伤和修复

DNA损伤和修复机制对于维持DNA完整性至关重要。细胞DNA的损伤与突变、癌症发展等有关。

DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

Discover Bioactive Small Molecules for Cell Cycle

Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.

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High-dose cytarabine (24 g/m2) in combination with idarubicin (HiDAC-3) results in high first-cycle response with limited gastrointestinal toxicity in adult acute myeloid leukaemia.

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全球贸易项目编号

货号	GTIN
C1768-500MG	04061833468029
C1768-100MG	04061833468005
C1768-1G	04061833468012
C1768-5G	04061833023846