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C221

羧基-PTIO 钾盐

Name: 羧基-PTIO 钾盐
Brand: SIGMA

synthetic (organic), ≥98% (TLC), NO scavenger, powder

别名:

2-（4-羧基苯基）-4,4,5,5-四甲基咪唑啉-1-氧基-3-氧化物钾盐, 2-（4-羧基苯基）-4,5-二氢-4,4,5,5-四甲基-1H-咪唑-1-基氧基-3-氧化物钾盐

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关于此项目

经验公式（希尔记法）:

C₁₄H₁₆KN₂O₄

化学文摘社编号:

148819-94-7

分子量:

315.39

UNSPSC Code:

12352200

PubChem Substance ID:

24892474

NACRES:

NA.32

MDL number:

MFCD00216153

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属性

产品名称

羧基-PTIO 钾盐,

biological source

synthetic (organic)

Quality Level

100

assay

≥98% (TLC)

form

powder

mp

>270 °C

solubility

H₂O: 100 mg/mL, DMSO: soluble (lit.)(lit.), methanol: soluble (lit.)(lit.)

storage temp.

2-8°C

SMILES string

[K+].CC1(C)N([O])C(c2ccc(cc2)C([O-])=O)=[N+]([O-])C1(C)C

InChI

1S/C14H17N2O4.K/c1-13(2)14(3,4)16(20)11(15(13)19)9-5-7-10(8-6-9)12(17)18;/h5-8H,1-4H3,(H,17,18);/q;+1/p-1

InChI key

VYEUQMVIGXFZQU-UHFFFAOYSA-M

说明

General description

2-（4-羧苯基）-4,4,5,5-四甲基咪唑啉-1-氧基-3-氧化物（羧基-PTIO）主要被认为是一氧化氮（NO）清除剂。

Application

羧基-PTIO钾盐通过检查反应混合物中羟基自由基或硝酸的生成情况，确定反应混合物中一氧化氮的生成情况。还可添加至神经元，分析其对葡萄糖/氧气/血清剥夺（GOSD）状态的影响（4）

Biochem/physiol Actions

羧基-PTIO可以与一氧化氮（NO）快速反应生成二氧化氮（NO₂）。可用于预防体内脂多糖刺激引起的低血压和内毒素性休克。羧基-PTIO还可以阻断体外 NO刺激造成的血管松弛。

其与一氧化氮反应可形成羧基-PTI衍生物，产物可进一步抑制一氧化氮合成酶的活性。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Nitric Oxide and Iron Signaling Cues Have Opposing Effects on Biofilm Development in Pseudomonas aeruginosa.

Xinyi Zhu et al.

Applied and environmental microbiology, 85(3) (2018-11-28)

While both iron and nitric oxide (NO) are redox-active environmental signals shown to regulate biofilm development, their interaction and roles in regulating biofilms have not been fully elucidated. In this study, exposure of Pseudomonas aeruginosa biofilms to exogenous NO inhibited

Interference of carboxy-PTIO with nitric oxide-and peroxynitrite-mediated reactions

Pfeiffer S, et al.

Free Radical Biology & Medicine, 22(5), 787-794 (1997)

Therapeutic effects of imidazolineoxyl N-oxide against endotoxin shock through its direct nitric oxide-scavenging activity.

M Yoshida et al.

Biochemical and biophysical research communications, 202(2), 923-930 (1994-07-29)

We recently found a new class of nitric oxide (NO) antidote, i.e., 2-phenyl-4,4,5,5,-tetramethylimidazoline-1-oxyl-3-oxide derivatives (PTIOs). It has a potent inhibitory action against endothelium-derived relaxing factor. Here, we report the effect of a water-soluble carboxy derivative of PTIO (carboxy-PTIO) on endotoxin

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全球贸易项目编号

货号	GTIN
C221-10MG	04061833475379