C2522
碳酸酐酶同工酶 II 来源于牛红细胞
lyophilized powder, ≥3,000 W-A units/mg protein
别名:
碳酸水解酶, 碳酸盐脱水酶, 碳酸酐酶 II
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-576-6
MDL number:
Specific activity:
≥3,000 W-A units/mg protein
Biological source:
bovine erythrocytes
biological source
bovine erythrocytes
Quality Level
form
lyophilized powder
specific activity
≥3,000 W-A units/mg protein
mol wt
30 kDa
pI
~5.9
storage temp.
−20°C
Application
Sigma 公司的碳酸酐酶已被用于通过测量结合亲和力和化学计量学来分析酶的热力学稳定性。在大鼠自身免疫性胰腺炎研究期间，还使用该酶生成了对碳酸酐酶特异性的 CD 4 + T 细胞系。
Biochem/physiol Actions
碳酸酐酶是一种锌金属酶，分子量约为 30,000 Da。这种酶催化二氧化碳水合生成碳酸。参与 pH 和 CO 2 动态平衡、碳酸氢盐和 CO 2 的转运、生物合成反应、骨吸收、钙化、致瘤等许多生理和病理过程。因此，阻断该酶的抑制剂可能对青光眼、癫痫和帕金森氏病具有治疗意义。
Other Notes
一个 Wilbur-Anderson (W-A) 单位每分钟将导致 0.02 MTrizma 缓冲液的 pH 值在 0°C 下从 8.3 降至 6.3（一个 W-A 单位基本上相当于一个 Roughton-Booth 单位）。
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signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
低风险生物材料
动植物源性产品
此项目有
实验方案
Enzymatic Assay of Carbonic Anhydrase for Wilbur-Anderson Units (EC 4.2.1.1)
Amelia Pollard et al.
Aging, 8(10), 2425-2436 (2016-10-16)
Carbonic anhydrase inhibitors are used to treat glaucoma and cancers. Carbonic anhydrases perform a crucial role in the conversion of carbon dioxide and water into bicarbonate and protons. However, there is little information about carbonic anhydrase isoforms during the process
Maria M Garcia-Alai et al.
Nature communications, 9(1), 328-328 (2018-01-25)
In clathrin-mediated endocytosis, adapter proteins assemble together with clathrin through interactions with specific lipids on the plasma membrane. However, the precise mechanism of adapter protein assembly at the cell membrane is still unknown. Here, we show that the membrane-proximal domains
Todd S Davidson et al.
The American journal of pathology, 166(3), 729-736 (2005-03-04)
Autoimmune pancreatitis (AIP), a recently defined disease of unknown etiology, is characterized by inflammatory infiltrates in the pancreas with conspicuous involvement of the ducts. The disease clinically manifests in humans as epigastric pain, weight loss, and jaundice. This report describes
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C2522-100MG | 04061833484135 |
| C2522-5MG | 04061833484159 |
| C2522-25MG | 04061833484142 |