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C2538

卡铂

DNA cross-linking agent, powder

别名:

顺 - 二氨基（1，1-环丁烷二羧酸）铂

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关于此项目

线性分子式:
[C4H6(CO2)2]Pt(NH3)2
化学文摘社编号:
41575-94-4
分子量:
371.25
NACRES:
NA.77
PubChem Substance ID:
24278303
UNSPSC Code:
12352200
EC Number:
255-446-0
MDL number:
MFCD00070464
Form:
powder
Quality level:
100
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产品名称

卡铂,

form

powder

Quality Level

100

antibiotic activity spectrum

neoplastics

originator

Bristol-Myers Squibb

SMILES string

N.N.O=C1O[Pt]OC(=O)C12CCC2

InChI

1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2

InChI key

OLESAACUTLOWQZ-UHFFFAOYSA-L

General description

卡铂被用于治疗睾丸癌、卵巢癌和乳腺癌。

Application

卡铂可用于：
  • 用于化疗性血小板减少小鼠模型及治疗
  • 诱导大量结直肠癌细胞死亡
  • 评估细胞增殖和化疗敏感性
  • 作为抑制细胞生长的阳性对照

Biochem/physiol Actions

卡铂是一种铂类抗肿瘤药物，通过与邻近的鸟嘌呤残基形成链内交联来破坏DNA。肿瘤通过DNA错配修复(MMR)活性的丧失以及由此导致的程序性细胞死亡诱导的减少而获得对这些药物的抗性。

Features and Benefits

该化合物是细胞凋亡研究的推荐产品。点击此处了解更多特色细胞凋亡产品。在sigma.com/discover-bsm 上了解有关生物活性小分子在其他研究领域的更多信息。
该化合物由Bristol-Myers Squibb开发。要浏览其他药物开发的化合物和已批准药物/候选药物的列表，请单击此处。

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pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Muta. 1B - Repr. 1B - Resp. Sens. 1 - Skin Sens. 1

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCK1243
MKCK1244
MKCF9647
MKCC6970
MKBZ8825V

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商品

DNA损伤和修复

DNA损伤和修复机制对于维持DNA完整性至关重要。细胞DNA的损伤与突变、癌症发展等有关。

DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

Discover Bioactive Small Molecules for Cell Cycle

Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.

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全球贸易项目编号

货号GTIN
C2538-100MG04061833484180
C2538-250MG04061833484197