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C271

CX546

Name: CX546
Brand: SIGMA

≥98% (HPLC), solid

别名:

1-(1,4-Benzodioxan-6-ylcarbonyl)piperidine

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关于此项目

经验公式（希尔记法）:

C₁₄H₁₇NO₃

化学文摘社编号:

215923-54-9

分子量:

247.29

NACRES:

NA.77

PubChem Substance ID:

24277960

UNSPSC Code:

12352200

MDL number:

MFCD01860868

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

protect from light

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属性

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

white to off-white

solubility

DMSO: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

O=C(N1CCCCC1)c2ccc3OCCOc3c2

InChI

1S/C14H17NO3/c16-14(15-6-2-1-3-7-15)11-4-5-12-13(10-11)18-9-8-17-12/h4-5,10H,1-3,6-9H2

InChI key

LJUNPHMOGNFFOS-UHFFFAOYSA-N

Gene Information

human ... GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)

说明

General description

CX546, a benzoylpiperidine derivative ampakine is an analog of CX516.

Application

CX546 has been used as positive allosteric modulator for the glutamatergic receptor α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) in mice.

Biochem/physiol Actions

CX546 has antipsychotic functionality and has the potential to treat schizophrenia. It improves the defects associated with the prepulse inhibition (PPI) and latent inhibition (LI) in mice lacking metabotropic glutamate receptor type 5 (mGluR5). Additionally, CX546 potentiates synaptic plasticity, elicits neuroprotection and promotes the neurotrophin expression.

Positive AMPA glutamate receptor modulator.

Disclaimer

Photosensitive

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Micro-electrode array recordings reveal reductions in both excitation and inhibition in cultured cortical neuron networks lacking Shank3.

C Lu et al.

Molecular psychiatry, 21(2), 159-168 (2015-11-26)

Numerous risk genes have recently been implicated in susceptibility to autism and schizophrenia. Translating such genetic findings into disease-relevant neurobiological mechanisms is challenging due to the lack of throughput assays that can be used to assess their functions on an

Ampakines: Labelling with ¹¹C for PET distribution studies.

Rogers, et al.

Journal of Labelled Compounds & Radiopharmaceuticals, 40, 645-647 (1997)

AMPAkines Target the Nucleus Accumbens to Relieve Postoperative Pain.

Chen Su et al.

Anesthesiology, 125(5), 1030-1043 (2016-10-19)

AMPAkines augment the function of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in the brain to increase excitatory outputs. These drugs are known to relieve persistent pain. However, their role in acute pain is unknown. Furthermore, a specific molecular and anatomic target for

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全球贸易项目编号

货号	GTIN
C271-10MG	04061832081533
C271-50MG	04061832081540