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C277

Chloro-IB-MECA

Name: Chloro-IB-MECA
Brand: SIGMA

solid, ≥98% (HPLC)

别名:

2-Chloro-N⁶-(3-iodobenzyl)-adenosine-5′-N-methyluronamide, Cl-IB-MECA

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关于此项目

经验公式（希尔记法）:

C₁₈H₁₈ClIN₆O₄

化学文摘社编号:

163042-96-4

分子量:

544.73

NACRES:

NA.77

PubChem Substance ID:

24278354

UNSPSC Code:

12352200

MDL number:

MFCD01861178

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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属性

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: >20 mg/mL

SMILES string

CNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(NCc4cccc(I)c4)nc(Cl)nc23

InChI

1S/C18H18ClIN6O4/c1-21-16(29)13-11(27)12(28)17(30-13)26-7-23-10-14(24-18(19)25-15(10)26)22-6-8-3-2-4-9(20)5-8/h2-5,7,11-13,17,27-28H,6H2,1H3,(H,21,29)(H,22,24,25)/t11-,12+,13-,17+/m0/s1

InChI key

IPSYPUKKXMNCNQ-PFHKOEEOSA-N

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)

说明

Biochem/physiol Actions

2-chloro-N(6)-(3-iodobenzyl)adenosine-5′-N-methylcarboxamide (Cl-IB-MECA) is a adenosine receptor. It protects against myocardial ischemia/reperfusion injury in mice.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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The A3 adenosine receptor agonist 2-Cl-IB-MECA facilitates epileptiform discharges in the CA3 area of immature rat hippocampal slices

Laudadio MA, et al.

Epilepsy Research, 59(2), 83-94 (2004)

A novel cardioprotective function of adenosine A1 and A3 receptors during prolonged simulated ischemia.

K Stambaugh et al.

The American journal of physiology, 273(1 Pt 2), H501-H505 (1997-07-01)

The possible cardioprotective roles of adenosine A1 and A3 receptors were investigated in a cardiac myocyte model of injury. The adenosine A3 receptor is a novel cardiac receptor capable of mediating potentially important cardioprotective functions. Prolonged hypoxia with glucose deprivation

Adenosine A3 receptor agonists protect HL-60 and U-937 cells from apoptosis induced by A3 antagonists.

Y Yao et al.

Biochemical and biophysical research communications, 232(2), 317-322 (1997-03-17)

The effects of novel, selective adenosine (ADO) A3 receptor antagonists of diverse structure on cells of the human HL-60 leukemia and U-937 lymphoma cell lines were examined. Both 3-ethyl 5-benzyl 2-methyl-6-phenyl-4-phenylethynyl-1,4-(+/-)-dihydropyridine-3, 5-dicarboxylate (MRS 1191, 0.5 microM) and 6-carboxy-methyl-5, 9-dihydro-9-methyl-2-phenyl-[1,2,4]-triazolo [5,1-a][2,7]naphthyridine

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全球贸易项目编号

货号	GTIN
C277-25MG	04061832269917
C277-500MG	04061833484586
C277-5MG	04061833006108