C2867
细胞色素 C 来源于马心脏
BioUltra, ≥99% (SDS-PAGE), powder, suitable for mammalian cell culture
别名:
CYC, CytC, Cytochrome c 来源于马心脏
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关于此项目
Form:
powder
Assay:
≥99% (SDS-PAGE)
Biological source:
horse heart
Mol wt:
12,384
biological source
horse heart
Quality Level
product line
BioUltra
assay
≥99% (SDS-PAGE)
form
powder
mol wt
12,384
storage condition
(Tightly closed Dry)
technique(s)
cell culture | mammalian: suitable
solubility
water: 10 mg/mL, dark red-brown
UniProt accession no.
storage temp.
−20°C
Gene Information
horse ... CYCS(100053958)
General description
细胞色素C(Cyt C)是一种核DNA编码蛋白。它来源于它的前体脱血红素细胞色素 c，并可以穿过线粒体外膜。
研究领域：细胞凋亡
研究领域：细胞凋亡
Application
来自马心脏的细胞色素c已被用于制备合成和标定生物素化细胞色素 c的储备溶液。 它还被用作反应缓冲液的成分，该缓冲液可用于染色电子传输链（ETC）复合物IV及用蓝色非变性凝胶电泳确定该复合物活性。
马的细胞色素c经过H2O2和UV 处理后的特异性位点和氧化程度已经过表征。研究表明这些位点可能可用作细胞内氧化环境的生物标记。
Biochem/physiol Actions
细胞色素 C（Cyt C）通过激活半胱天冬酶 3（一种死亡蛋白酶），充当细胞凋亡的有效信号分子。它在血红素结合中发挥作用，有细胞色素 c血红素裂解酶的帮助加速了细胞色素 c释放到线粒体膜间隙中。Cyt C还通过与心磷脂相互作用表现出脂质结合的能力，心磷脂是一种磷脂，可启动蛋白质展开并激活Cyt C中的过氧化物酶功能。
细胞色素c的主要身份是电子载体线粒体蛋白。在细胞内，细胞色素c能够在二价铁和三价铁之间转化，使得它称为了有效的生物电子载体，在动植物细胞内氧化中起到很重要的作用。它通常被视作呼吸作用催化剂，在呼吸底物和氧气之间形成必需的电子桥
Preparation Note
C2506 的进一步纯化
采用 TCA 制备。
Other Notes
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
低风险生物材料
此项目有
Yuning Hong et al.
Journal of the American Chemical Society, 134(45), 18713-18723 (2012-10-17)
Interactions of cytochrome c (cyt c) with cardiolipin (CL) partially unfold the protein, activating its peroxidase function, a critical event in the execution of apoptosis. However, structural features of the altered protein species in the heterogeneous ensemble are difficult to
Raja Ghosh et al.
Journal of chromatography. A, 1515, 138-145 (2017-08-13)
In a recent paper, box-shaped or cuboid packed bed devices have been proposed as alternative to columns for chromatographic separations. We first propose a mathematical model for residence time distribution in such devices. Based on it, we examine factors likely
Diana Bahhir et al.
PLoS genetics, 15(10), e1008410-e1008410 (2019-10-05)
Mitochondria have been increasingly recognized as a central regulatory nexus for multiple metabolic pathways, in addition to ATP production via oxidative phosphorylation (OXPHOS). Here we show that inducing mitochondrial DNA (mtDNA) stress in Drosophila using a mitochondrially-targeted Type I restriction
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C2867-10MG | 04061833484692 |
| C2867-50MG | 04061833269718 |