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C2932

氯化白屈菜赤碱

Name: 氯化白屈菜赤碱
Brand: SIGMA

plant, ≥95% (TLC), protein kinase C inhibitor, powder

别名:

1,2-Dimethoxy-N-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride, Toddaline chloride

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关于此项目

经验公式（希尔记法）:

C₂₁H₁₈ClNO₄

化学文摘社编号:

3895-92-9

分子量:

383.82

UNSPSC Code:

12352200

PubChem Substance ID:

24278305

NACRES:

NA.77

MDL number:

MFCD00060717

Assay:

≥95% (TLC)

Form:

powder

Quality level:

100

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属性

产品名称

氯化白屈菜赤碱, ≥95% (TLC), powder

biological source

plant

Quality Level

100

assay

≥95% (TLC)

form

powder

color

yellow to orange

mp

213.0-214.0 °C

solubility

DMSO: 2 mg/mL

storage temp.

−20°C

SMILES string

Cl.COc1ccc2-c3ccc4cc5OCOc5cc4c3[N](C)=Cc2c1OC

InChI

1S/C21H18NO4.ClH/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22;/h4-10H,11H2,1-3H3;1H

InChI key

SUPBMPBJXZDANZ-UHFFFAOYSA-N

说明

General description

Chelerythrine chloride (CHE), a benzophenanthridine alkaloid is an inhibitor of protein kinase C (PKC). It is the active component of Macleaya cordata.

Application

Chelerythrine chloride has been used:

as a supplement in heat-inactivated late-embryo extract or late-embryo extract to inhibit protein kinase C (PKC) activity
for in vitro Xenopus experiments
as a PKC inhibitor in HL-1 cells, to block the PKC pathway to study its effects on doxazosin-induced galectin-3 and collagen expression

Biochem/physiol Actions

Chelerythrine chloride (CHE) is capable of preventing the growth and apoptosis in human gastric cancer BGC-823 cells. It possesses several biological effects and also can induce the phosphorylation of a ~20 kDa protein present in the mitochondrial fraction of the rat retina.

Features and Benefits

This compound is featured on the P2 Receptors: P2X Ion Channel Family and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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pictograms

GHS07

signalword

Warning

hcodes

H302 + H312 + H332,H315,H319,H335

pcodes

P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

涉药品监管产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Protein kinase C promotes cardiac fibrosis and heart failure by modulating galectin-3 expression

Song X, et al.

Biochimica et Biophysica Acta - Molecular Cell Research, 1853(2), 513-521 (2015)

Doxazosin stimulates galectin-3 expression and collagen synthesis in HL-1 cardiomyocytes independent of protein kinase C pathway

Qian X, et al.

Frontiers in Pharmacology, 7, 495-495 (2016)

Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C.

W D Jarvis et al.

Cancer research, 54(7), 1707-1714 (1994-04-01)

The present studies were undertaken to characterize further the potential role of protein kinase C (PKC) in the regulation of apoptosis in HL-60 promyelocytic leukemia cells. The capacity of acute exposure to specific and nonspecific pharmacological inhibitors of PKC to

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全球贸易项目编号

货号	GTIN
C2932-1MG	04061826131985
C2932-5MG	04061833484920