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关于此项目
线性分子式:
ClC6H4CH2CH(NH2)CO2CH3·HCl
化学文摘社编号:
分子量:
250.12
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
238-024-0
MDL number:
产品名称
4-氯-DL-苯基丙氨酸甲酯 盐酸盐,
form
powder
mp
186-189 °C (lit.)
storage temp.
−20°C
SMILES string
Cl.COC(=O)C(N)Cc1ccc(Cl)cc1
InChI
1S/C10H12ClNO2.ClH/c1-14-10(13)9(12)6-7-2-4-8(11)5-3-7;/h2-5,9H,6,12H2,1H3;1H
InChI key
GCBCWTWQAFLKJG-UHFFFAOYSA-N
Gene Information
human ... TPH1(7166), TPH2(121278)
General description
4-氯-DL-苯丙氨酸甲酯盐酸盐刺激妊娠小鼠的葡萄糖耐受不良。研究表明4-氯-DL-苯丙氨酸甲酯盐酸盐与啮齿动物的认知缺陷有关。
Application
4-氯- DL -苯丙氨酸甲酯盐酸盐已用于诱导大鼠 5-羟色胺 (5-HT) 耗竭。
Biochem/physiol Actions
色氨酸羟化酶抑制剂。
色氨酸羟化酶抑制剂。比对氯苯基丙氨酸更易穿越血脑屏障。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Jessica E Monk et al.
Frontiers in behavioral neuroscience, 12, 246-246 (2018-11-09)
Negative affective states such as anxiety and depression pose a risk to animal welfare, however, practical tests for assessing these states in animals are limited. In humans, anxious individuals are shown to pay more attention toward threatening information than non-anxious
Serotonin regulates pancreatic beta cell mass during pregnancy
Kim H, et al.
Nature Medicine, 16(7), 804-804 (2010)
Serotonin depletion results in a decrease of the neuronal activation caused by rivastigmine in the rat hippocampus
Kornum BR, et al.
Brain Research, 1073, 262-268 (2006)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C3635-25G | 04061833618660 |
| C3635-1G | 04061826690192 |
| C3635-5G | 04061833427637 |