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C3735

细胞色素P450 人

Name: 细胞色素P450 人
Brand: SIGMA

1A1 Isozyme Microsomes, with P450 Reductase, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

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关于此项目

UNSPSC Code:

12161501

NACRES:

NA.47

EC 号:

1.6.2.4 (BRENDA, IUBMB)

MDL number:

MFCD03456520

Specific activity:

≥4 units/pmol enzyme

Biological source:

human

Recombinant:

expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

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属性

biological source

human

Quality Level

200

recombinant

expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

form

solution

specific activity

≥4 units/pmol enzyme

mol wt

45-60 kDa

packaging

vial of 0.5 nmol

technique(s)

activity assay: suitable

solubility

water: soluble

suitability

suitable for molecular biology

UniProt accession no.

P04798

application(s)

cell analysis

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... CYP1A1(1543)

说明

General description

研究领域：免疫和CKS

细胞色素P450(CYP)酶系是由P450基因编码的一系列酶。这类酶是膜结合的血红素蛋白。主要存在于肝脏内质网中。’

Biochem/physiol Actions

细胞色素P450是异质性同工酶家族，其主要功能是氧化小分子，发挥中间代谢（如脂肪酸）功能和对外源性化合物（药物或毒素）进行解毒。有些同工型具有有限的底物特异性，而其他同工酶则比较混杂。CYP1A1亚型催化乙氧基试卤灵的7-脱乙基。细胞色素P450(CYP)在外源物解毒、细胞代谢和稳态中起重要作用。药物相互作用的一种主要机制就是激活或抑制这类酶。CYP酶可被多种外源物和内源底物经由受体依赖途径转录激活。基于代谢的药物相互作用主要影响就是抑制这类酶，许多化疗药物可通过抑制或诱导细胞色素P450酶系引发药物互作。

Physical form

100 mM 磷酸钾缓冲液，pH 7.4溶液。

Preparation Note

含人CYP1A1和重组人NADPH-P450还原酶的微粒体。

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品

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历史批次信息供参考:

分析证书(COA)

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Effects of frequently applied carbon monoxide releasing molecules (CORMs) in typical CO-sensitive model systems - A comparative in vitro study.

David Stucki et al.

Archives of biochemistry and biophysics, 687, 108383-108383 (2020-04-27)

Intracellular carbon monoxide (CO) is a gaseous signaling molecule and is generated enzymatically by heme oxygenases upon degradation of heme to billiverdin. Target structures for intracellular produced CO are heme proteins including cytochrome c oxidase of the respiratory chain, cytochrome

Effect of TCDD exposure on CYP1A1 and CYP1B1 expression in explant cultures of human endometrium.

D P Bofinger et al.

Toxicological sciences : an official journal of the Society of Toxicology, 62(2), 299-314 (2001-07-14)

Endometriosis is a debilitating disease estimated to affect 10% of reproductive-age women and characterized by the growth of endometrial tissue outside of the uterus. The present study characterizes a human endometrial explant culture model for studying the direct effects of

Carbon monoxide releasing molecule 401 (CORM-401) modulates phase I metabolism of xenobiotics.

Moritz Walter et al.

Toxicology in vitro : an international journal published in association with BIBRA, 59, 215-220 (2019-04-21)

Next to its well-studied toxicity, carbon monoxide (CO) is recognized as a signalling molecule in various cellular processes. Thus, CO-releasing molecules (CORMs) are of considerable interest for basic research and drug development. Aim of the present study was to investigate

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全球贸易项目编号

货号	GTIN
C3735-1VL	04061826590676