C3912
8-(4-氯苯硫基）-腺苷 3′,5′-环单磷酸 钠盐 钠盐
≥97.0% (HPLC), cAMP analog, powder
别名:
pCPT-cAMP
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关于此项目
经验公式（希尔记法）:
C16H14ClN5NaO6PS
化学文摘社编号:
分子量:
493.79
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
299-413-9
MDL number:
产品名称
8-(4-氯苯硫基）-腺苷 3′,5′-环单磷酸 钠盐 钠盐, ≥97.0% (HPLC), powder
Quality Level
assay
≥97.0% (HPLC)
form
powder
color
white
solubility
H2O: 25 mg/mL
storage temp.
−20°C
SMILES string
[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)c(Sc5ccc(Cl)cc5)nc12
InChI
1S/C16H15ClN5O6PS.Na/c17-7-1-3-8(4-2-7)30-16-21-10-13(18)19-6-20-14(10)22(16)15-11(23)12-9(27-15)5-26-29(24,25)28-12;/h1-4,6,9,11-12,15,23H,5H2,(H,24,25)(H2,18,19,20);/q;+1/p-1/t9-,11-,12-,15-;/m1./s1
InChI key
YIJFVHMIFGLKQL-DNBRLMRSSA-M
Gene Information
human ... PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
Application
8-（4-硫代氯苯基）腺苷3′5′-环单磷酸用于：
- 上调细胞胆固醇泵（三磷酸腺苷（ATP）结合盒（ABC）转运蛋白1，ABCA-1）
- 葡萄糖生成测定
- 刺激气道上皮细胞的囊性纤维化跨膜传导调节因子（CFTR）通道
Biochem/physiol Actions
膜通透性 cAMP 类似物。用作 cAMP 依赖性蛋白激酶 (PKA) 的选择性激活剂。抑制 cGMP 依赖性磷酸二酯酶，在较高浓度时，抑制 cAMP 依赖性磷酸二酯酶。抑制 n-甲酰-Met-Leu-Phe 刺激的磷酸肌醇水解和分泌，但不抑制白细胞中的血小板活化因子。使 HL-60 细胞更能抵抗 NO 诱导的 DNA 损伤。
Features and Benefits
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
Pierpaolo Moscariello et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 5(5), 1700897-1700897 (2018-06-08)
Neurological disorders are undoubtedly among the most alarming diseases humans might face. In treatment of neurological disorders, the blood-brain barrier (BBB) is a challenging obstacle preventing drug penetration into the brain. Advances in dendrimer chemistry for central nervous system (CNS)
H Ali et al.
The Journal of biological chemistry, 273(18), 11012-11016 (1998-06-06)
Formylated peptides (e.g. n-formyl-Met-Leu-Phe (fMLP)) and platelet-activating factor (PAF) mediate chemotactic and cytotoxic responses in leukocytes through receptors coupled to G proteins that activate phospholipase C (PLC). In RBL-2H3 cells, fMLP utilizes a pertussis toxin (ptx)-sensitive G protein to activate
J F Desaphy et al.
The American journal of physiology, 275(6 Pt 1), C1465-C1472 (1998-12-09)
Although the skeletal muscle sodium channel is a good substrate for cAMP-dependent protein kinase (PKA), no functional consequence was observed for this channel expressed in heterologous systems. Therefore, we investigated the effect of 8-(4-chlorophenylthio)adenosine 3',5'-cyclic monophosphate (CPT-cAMP), a membrane-permeable cAMP
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C3912-50MG | 04061833486573 |
| C3912-100MG | 04061833486559 |
| C3912-10MG | 04061833486566 |