C4396
碳酸酐酶I 来源于人类红细胞
别名:
碳酸盐脱水酶, 碳酸酐酶同工酶I, 碳酸酯水解酶
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352204
NACRES:
NA.25
EC Number:
232-576-6
MDL number:
Specific activity:
100-500 W-A units/mg protein
Application
来自人红细胞（HCA）的碳酸酐酶已被用于研究碳酸酐酶（CA）的熔球态。分子伴侣样α-晶状体蛋白能够与这种状态的酶结合并阻止其聚集。 Sigma的酶已被用于分析酶的热力学稳定性。 此外，已经评估了该酶在人非小细胞肺癌中的临床意义。
Biochem/physiol Actions
碳酸酐酶是一种锌金属酶，其分子量约为30,000Da。该酶可以催化二氧化碳的水合，形成碳酸。它参与一些重要过程，如pH和CO2稳态、碳酸氢盐和CO2的转运、生物合成反应、骨吸收、钙化和致瘤性。因此，该酶是一个重要的抑制剂靶标，在青光眼、癫痫和帕金森氏病等各种病症中具有临床应用价值。
Preparation Note
色谱
纯化的。
纯化的。
Other Notes
在0 °C条件下，一Wilbur-Anderson (W-A)单位可使0.02M Trizma缓冲液pH在一分钟内从8.3降至 6.3。（一W-A单位基本上相当于一Roughton-Booth单位。）
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flash_point_c
Not applicable
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
法规信息
高风险级别生物产品--人源产品
此项目有
实验方案
Enzymatic Assay of Carbonic Anhydrase for Wilbur-Anderson Units (EC 4.2.1.1)
K Rajaraman et al.
The Journal of biological chemistry, 271(44), 27595-27600 (1996-11-01)
alpha-Crystallin, a multimeric protein, exhibits chaperone-like activity in preventing aggregation of several proteins. We have studied the chaperone-like activity of alpha-crystallin toward heat-induced aggregation of bovine and human carbonic anhydrase. Human carbonic anhydrase aggregates at 60 degrees C, while bovine
Whei Ling Chiang et al.
Cancer letters, 188(1-2), 199-205 (2002-10-31)
This study was designed to elucidate the possible relationship between the expression of cytosolic carbonic anhydrase (CA) and non-small cell lung cancer (NSCLC). The activity and protein expression patterns of carbonic anhydrase I (CAI) and II (CAII) of 70 NSCLC
Daumantas Matulis et al.
Biochemistry, 44(13), 5258-5266 (2005-03-30)
ThermoFluor (a miniaturized high-throughput protein stability assay) was used to analyze the linkage between protein thermal stability and ligand binding. Equilibrium binding ligands increase protein thermal stability by an amount proportional to the concentration and affinity of the ligand. Binding
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C4396-1MG | 04061826674116 |
| C4396-25MG | 04061833260975 |
| C4396-5MG | 04061833260982 |