C4407
Human Collagen Type III
from human placenta, powder, suitable for cell culture
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关于此项目
Form:
powder
Assay:
≥90% (GE)
Biological source:
human placenta
产品名称
胶原蛋白 来源于人类胎盘, Bornstein and Traub Type III (Sigma Type X), powder
biological source
human placenta
Quality Level
assay
≥90% (GE)
form
powder
technique(s)
cell culture | mammalian: suitable
impurities
HIV, hepatitis B and hepatitis C, none detected
solubility
aqueous acid: soluble
UniProt accession no.
storage temp.
2-8°C
Gene Information
human ... COL3A1(1300)
Application
来自人胎盘的胶原蛋白已用于评估奎宁对气道上皮细胞的生物电效应、研究工程化慢病毒裂解肽的选择性毒性以及用于颗粒聚集测定以快速检测金黄色葡萄球菌（ Staphylococcus aureus）上的纤连蛋白、纤维蛋白原和胶原蛋白受体。 在表征人肺肿瘤相关抗原时，它还用于镁依赖型胶原蛋白结合试验。
Preparation Note
它是冻干粉，可以1 mg/mL溶于无菌的.5 M乙酸、PBS或水中。 PBS溶液在-20°C下至少可稳定保存一年。
Analysis Note
SDS聚丙烯酰胺凝胶电泳在和基底膜胶原蛋白相同的还原条件下测试，得到三条主要条带。
Other Notes
所有胶原蛋白分子均由以三螺旋构象排列的三条肽链组成，其一级结构主要以三个氨基酸作为重复基序，即每隔两个氨基酸是一个甘氨酸残基，其前面的两个位置通常为脯氨酸或4-羟基脯氨酸。
胶原蛋白被分为许多种结构和遗传性不同的类型。 我们使用 Bornstein和Traub提出的系统命名法。 小心不要混淆Sigma命名系统和通用的胶原蛋白分类类型。
Disclaimer
该产品应在2-8 °C下保存，在此条件下活性可保持2年。
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Johana Hrdinova et al.
International journal of molecular sciences, 23(4) (2022-02-27)
The plasmatic von Willebrand factor (VWF) circulates in a compact form unable to bind platelets. Upon shear stress, the VWF A1 domain is exposed, allowing VWF-binding to platelet glycoprotein Ib-V-IX (GPIbα chain). For a better understanding of the role of
Natalie J Jooss et al.
International journal of molecular sciences, 20(11) (2019-06-12)
Platelet interaction with collagens, via von Willebrand factor, is a potent trigger of shear-dependent thrombus formation mediated by subsequent engagement of the signaling collagen receptor glycoprotein (GP)VI, enforced by integrin α2β1. Protein tyrosine kinase Syk is central in the GPVI-induced
Sanne L N Brouns et al.
Scientific reports, 10(1), 11910-11910 (2020-07-19)
In haemostasis and thrombosis, platelet, coagulation and anticoagulation pathways act together to produce fibrin-containing thrombi. We developed a microspot-based technique, in which we assessed platelet adhesion, platelet activation, thrombus structure and fibrin clot formation in real time using flowing whole
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C4407-1MG | 04061833492123 |
| C4407-25MG | 04061833260999 |
| C4407-5MG | 04061833492130 |