主要文件

查看所有文档

C4493

葫芦素 I

Name: 葫芦素 I
Brand: SIGMA

≥95% (HPLC), solid

别名:

2,16α,20,25-四羟基-9-甲基-19-去甲-9β,10α-羊毛甾-1,5,23-三烯-3,11,22-三酮, JSI-124, NSC 521777, 喷瓜苦素 B

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₃₀H₄₂O₇ · xH₂O

化学文摘社编号:

2222-07-3

分子量:

514.65 (anhydrous basis)

MDL number:

MFCD09971044

UNSPSC Code:

12352200

PubChem Substance ID:

329775065

EC Number:

218-736-8

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

solid

Quality level:

100

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

Quality Level

100

assay

≥95% (HPLC)

form

solid

color

white to off-white

solubility

DMSO: >5 mg/mL

storage temp.

−20°C

SMILES string

O.CC(C)(O)\C=C\C(=O)[C@](C)(O)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4[C@@H](C=C(O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C

InChI

1S/C30H42O7.H2O/c1-25(2,36)12-11-21(33)30(8,37)23-19(32)14-27(5)20-10-9-16-17(13-18(31)24(35)26(16,3)4)29(20,7)22(34)15-28(23,27)6;/h9,11-13,17,19-20,23,31-32,36-37H,10,14-15H2,1-8H3;1H2/b12-11+;/t17-,19-,20+,23+,27+,28-,29+,30+;/m1./s1

InChI key

ZKDSPEWKSJCXQE-NEBRQAMTSA-N

说明

Biochem/physiol Actions

葫芦素 I (JSI-124) 是一种新型的 JAK 激酶 2/信号转导子和转录激活子 3 (JAK2/STAT3) 信号通路选择性抑制剂，具有抗增殖和抗肿瘤属性。

葫芦素 I 是一种新型选择性 JAK/STAT3 抑制剂。

Features and Benefits

该化合物是受体分类及信号转导手册上JAK页面上的特色化合物。想要浏览手册的其他页面，请单击此处。

该化合物是激酶磷酸酶生物学研究的特色产品。点击此处，发现更多特色激酶磷酸酶生物学产品。在 sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子。

pictograms

GHS06

signalword

Danger

hcodes

H300

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 1 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

商品

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Inhibition of constitutive activation of STAT3 by curcurbitacin-I (JSI-124) sensitized human B-leukemia cells to apoptosis.

Ganchimeg Ishdorj et al.

Molecular cancer therapeutics, 9(12), 3302-3314 (2010-12-17)

Phosphorylation of STAT3 on serine 727 regulates gene expression and is found to be elevated in many B-leukemia cells including chronic lymphocytic leukemia (CLL). It is, however, unclear whether targeting STAT3 will be an effective antileukemia therapy. In this study

Cucurbitacin I elicits anoikis sensitization, inhibits cellular invasion and in vivo tumor formation ability of nasopharyngeal carcinoma cells.

Vivian W Y Lui et al.

Carcinogenesis, 30(12), 2085-2094 (2009-10-22)

Nasopharyngeal carcinoma (NPC) is an Asian-prevalent head and neck cancer with high invasiveness. Although several important risk factors for NPC development have been identified, there is currently no preventive strategy for NPC, even in endemic regions. Signal transducer and activator

Cucurbitacin I inhibits tumorigenic ability and enhances radiochemosensitivity in nonsmall cell lung cancer-derived CD133-positive cells.

Han-Shui Hsu et al.

Cancer, 117(13), 2970-2985 (2011-01-13)

Signal transducer and activator of transcription 3 (STAT3) signaling reportedly promotes tumor malignancy and recurrence in nonsmall cell lung cancer (NSCLC). It was demonstrated previously that the STAT3 pathway maintains the tumorigenicity and therapeutic resistance of malignant tumors as well

查看所有相关文献

全球贸易项目编号

货号	GTIN
C4493-1MG	04061833492246