C5624
隐丹参酮
≥98% (HPLC)
别名:
1,2,6,7,8,9-六氢-1,6,6-三甲基 - （R） - 菲啰啉（1,2-b）呋喃-10,11-二酮, 丹参酮 C, 隐丹参酮
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关于此项目
经验公式（希尔记法）:
C19H20O3
化学文摘社编号:
分子量:
296.36
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -80 to -99°, c = 0.5 in chloroform-d
storage condition
desiccated, protect from light
color
orange-brown
solubility
DMSO: ≥5 mg/mL
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
SMILES string
C[C@H]1COC2=C1C(=O)C(=O)c3c4CCCC(C)(C)c4ccc23
InChI
1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3/t10-/m0/s1
InChI key
GVKKJJOMQCNPGB-JTQLQIEISA-N
Biochem/physiol Actions
隐丹参酮是一种从亚洲药用植物丹参的根中分离出的醌类二萜。最新研究表明，该化合物是有效的 STAT3 抑制剂。隐丹参酮通过 JAK2 非依赖性机制快速抑制 STAT3 Tyr705 磷酸化。隐丹参酮通过与单体 STAT3 结合选择性抑制 STAT3 活化的细胞系，随后阻断二聚化并抑制 STAT3 转录调节活性。以前，研究据报道了该化合物通过抑制环加氧酶 II 活性和内皮素-1 的表达来消除炎症。丹参（Danshen）的干根在传统的东方医学中通常用于治疗循环障碍、肝病、冠心病、肝炎和慢性肾衰竭。
隐丹参酮是一种特异性 STAT3 抑制剂。它可以防止 STAT3 二聚化。
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存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Fu-Lin Zheng et al.
Chinese medical journal, 124(24), 4293-4298 (2012-02-22)
Cryptotanshinone (CT) is the major active constituent of Salvia miltiorrhiza Bunge. The present study was carried out to investigate the effects of CT on rats with adjuvant arthritis (AA). AA was induced by the metatarsal footpad injection with complete Freund's
Wentao Bi et al.
Talanta, 85(1), 701-706 (2011-06-08)
Ionic liquid-based extraction of medicinal or useful compounds from plants was investigated as an alternative to supercritical fluid, cloud point and conventional organic solvent extractions. The method integrated extraction and preconcentration. Medicinal products were first extracted by an ionic liquid
Yingjie Wei et al.
Molecules (Basel, Switzerland), 17(7), 8617-8632 (2012-07-20)
The study aimed to investigate the potential of zebrafish in imitating mammal phase I metabolism of natural compounds. Three diterpenoid quinones from Radix Salvia miltiorrhiza, namely tanshinone IIA (TIIA), cryptotanshinone (Cry) and tanshinone I (TI) were selected as model compounds
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C5624-25MG | 04061832631820 |
| C5624-5MG | 04061832631837 |