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Merck
CN

C5988

Anti-Calcium Channel (β1 subunit) antibody produced in rabbit

~1 mg/mL, fractionated antiserum, buffered aqueous solution

别名:

Anti-Voltage-dependent L-type calcium channel, β1 subunit

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
5
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biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

fractionated antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, mouse, human

concentration

~1 mg/mL

technique(s)

western blot: 5-10 μg/mL using rat brain tissue lysate

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CACNB1(782)
mouse ... Cacnb1(12295)
rat ... Cacnb1(50688)

General description

The gene CACNB1 (Calcium channel voltage-dependent subunit β 1) is mapped to human chromosome 17q11.2-q22.

Immunogen

synthetic peptide derived from the rat β1 calcium channel conjugated to KLH.

Application

Anti-Calcium Channel (β1 subunit) antibody produced in rabbit is suitable for western blot at a concentration of 5-10 μg/mL using rat brain tissue lysate

Biochem/physiol Actions

The CACNB1 (Calcium channel voltage-dependent subunit β 1) is an intracellular regulatory subunit of voltage-activated calcium channels that has significant impact on membrane expression and electrophysical characteristics of the channel. Calcium channel β subunits regulate voltage-dependent calcium currents through direct interaction with α1 subunits. CACNB1 is a target of miRNA-328. In mouse model, CACNB1 is involved in gene expression in muscle progenitor cells and regulates skeletal muscle mass during embryonic development by suppressing myogenin.

Physical form

Solution in phosphate buffered saline containing 0.08% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


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存储类别

10 - Combustible liquids

法规信息

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分析证书(COA)

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相关内容


R G Gregg et al.
Genomics, 15(1), 185-187 (1993-01-01)
A human clone containing a portion of the gene encoding several isoforms of the beta 1 subunit of voltage-dependent calcium channels was isolated and partially sequenced. The gene was mapped to chromosome 17 using the polymerase chain reaction with oligonucleotides
Solmaz Etemad et al.
Channels (Austin, Tex.), 8(4), 334-343 (2014-05-31)
Voltage-gated calcium channels regulate gene expression by controlling calcium entry through the plasma membrane and by direct interactions of channel fragments and auxiliary β subunits with promoters and the epigenetic machinery in the nucleus. Mutations of the calcium channel β(4)
Jackson Taylor et al.
The Journal of cell biology, 205(6), 829-846 (2014-06-18)
Voltage-gated calcium channel (Cav) β subunits are auxiliary subunits to Cavs. Recent reports show Cavβ subunits may enter the nucleus and suggest a role in transcriptional regulation, but the physiological relevance of this localization remains unclear. We sought to define



全球贸易项目编号

货号GTIN
C5988-100UG04061838070548