C6022
赛庚啶 盐酸盐 倍半水合物
≥98% (TLC), solid
别名:
水合哌啶4-(5H-二苯并[a，d]环庚基-5-亚烷基)-1-甲基-盐酸盐 (2:3)
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关于此项目
经验公式（希尔记法）:
C21H21N·HCl·1.5H2O
化学文摘社编号:
分子量:
350.88
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
213-535-1
NACRES:
NA.77
Quality Level
assay
≥98% (TLC)
form
solid
color
white to slightly yellow
solubility
ethanol: soluble, methanol: soluble
originator
Merck & Co., Inc., Kenilworth, NJ, U.S.
SMILES string
Cl.CN1CCC(\CC1)=C2/c3ccccc3C=Cc4ccccc24
InChI
1S/2C21H21N.2ClH.3H2O/c2*1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21;;;;;/h2*2-11H,12-15H2,1H3;2*1H;3*1H2
InChI key
ZEAUHIZSRUAMQG-UHFFFAOYSA-N
Gene Information
human ... HRH1(3269), HTR2A(3356), HTR2B(3357), HTR2C(3358)
Application
盐酸赛庚啶倍半水合物已被用于：
降钙素基因相关肽（CGRP）的抑制
- 检测5-羟色胺受体（5-HT）诱导的炎症中的抗炎活性
- 螃蟹中体内和体外生物检测中5-HT的抑制
- 胚胎生理性实验中5-HT的抑制
降钙素基因相关肽（CGRP）的抑制
Biochem/physiol Actions
赛庚啶盐酸盐倍半水合物是一种血清素受体（5-HT2 / 5-HT1C）拮抗剂、H1组胺受体拮抗剂和止痒剂。赛庚啶对5-HT的抑制作用可改善精神分裂症的认知功能。赛庚啶对治疗功能性胃肠道疾病（FGID）有效。食品药品监督管理局（FDA）批准的赛庚啶具有抗抑郁和抗血小板功能。它可有效地治疗血栓栓塞性疾病。赛庚啶能够抑制赖氨酸甲基转移酶7/9（Set7/9），导致乳腺癌细胞中雌激素受体（ERα）的表达减少和生长停滞。
Features and Benefits
该化合物是由Merck & Co., Inc., Kenilworth, NJ, U.S.开发的。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单， 请单击此处。
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Comparative anticholinergic activities of 10 histamine H1 receptor antagonists in two functional models
Orzechowski RF, et al.
European Journal of Pharmacology, 506(3), 257-264 (2005)
The antidepressant 5-HT2A receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function
Lin OA, et al.
PLoS ONE, 9(1), e87026-e87026 (2014)
S Kimura et al.
Immunological investigations, 27(6), 379-393 (1998-12-09)
For the immunopharmacological characterization of murine passive anaphylactic shock, the effects of antihistaminics and/or anti-platelet-activating factor (anti-PAF) agents were studied on the shock mediated by allogeneic monoclonal IgE and IgG1 antibodies and hyperimmune serum. IgE antibody-mediated shock was strongly suppressed
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C6022-100MG | 04061832089935 |
| C6022-1G | 04061825982090 |