C6303
Calphostin C
From microbial (Cladosporium cladosporioides), ≥90% (HPLC), protein kinase C inhibitor, powder
别名:
UCN-1028c
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C44H38O14
化学文摘社编号:
分子量:
790.76
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
钙磷蛋白C 来源于枝孢样枝孢霉, ≥90% (HPLC), powder
biological source
microbial (Cladosporium cladosporioides)
Quality Level
assay
≥90% (HPLC)
form
powder
color
red to brown
solubility
DMF: 1 mg/mL, DMSO: 1 mg/mL, ethanol: 1 mg/mL
storage temp.
−20°C
SMILES string
COc1cc(O)c2C(=O)C(OC)=C(CC(C)OC(=O)Oc3ccc(O)cc3)c4c5C(CC(C)OC(=O)c6ccccc6)=C(OC)C(=O)c7c(O)cc(OC)c(c57)c1c24
InChI
1S/C44H38O14/c1-20(56-43(50)22-10-8-7-9-11-22)16-25-31-32-26(17-21(2)57-44(51)58-24-14-12-23(45)13-15-24)42(55-6)40(49)34-28(47)19-30(53-4)36(38(32)34)35-29(52-3)18-27(46)33(37(31)35)39(48)41(25)54-5/h7-15,18-21,45-47H,16-17H2,1-6H3
InChI key
SRJYZPCBWDVSGO-UHFFFAOYSA-N
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
R F Bruns et al.
Biochemical and biophysical research communications, 176(1), 288-293 (1991-04-15)
Calphostin C, a secondary metabolite of the fungus Cladosporium cladosporioides, inhibits protein kinase C by competing at the binding site for diacylglycerol and phorbol esters. Calphostin C is a polycyclic hydrocarbon with strong absorbance in the visible and ultraviolet ranges.
M Begemann et al.
Anticancer research, 18(5A), 3139-3152 (1998-12-22)
Protein kinase C (PKC) is a central component in signal transduction and growth control and might be an appropriate target for the chemotherapy of human brain tumors. This study demonstrates that the staurosporine derivative Ro 31-8220, a potent PKC inhibitor
T Tamaoki et al.
Bio/technology (Nature Publishing Company), 8(8), 732-735 (1990-08-01)
Potent and specific inhibitors of protein kinase C have been found in streptomyces and fungi: Staurosporine, an alkaloid from Streptomyces sp., is the most potent inhibitor of protein kinases with an IC50 in the nanomolar range. UCN-01 (7-hydroxy staurosporine), isolated
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C6303-1MG | 04061833511138 |
| C6303-.1MG | 04061833511121 |