C6499
CTB
≥98% (HPLC)
别名:
CTPB, N-（4-氯-3-三氟甲基-苯基）-2-乙氧基-苯甲酰胺
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关于此项目
经验公式（希尔记法）:
C16H13ClF3NO2
化学文摘社编号:
分子量:
343.73
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
SMILES string
FC(F)(F)c1c(ccc(c1)NC(=O)c2c(cccc2)OCC)Cl
InChI key
YDXZSNHARVUYNM-UHFFFAOYSA-N
General description
CTB（N-（4-氯-3-三氟甲基-苯基）-2-乙氧基-苯甲酰胺）来源于漆树酸。
Application
CTB 已用于研究其P53 蛋白乙酰化的凋亡作用。
Biochem/physiol Actions
HAT 的小分子激活剂如 CTB（N-（4-氯-3-三氟甲基-苯基）-2-乙氧基-苯甲酰胺）可直接改变染色质乙酰化。可作为治疗神经精神、神经发育和神经退行性疾病等认知功能障碍并发症的药物。
CTPB 是第一个已知的组蛋白乙酰转移酶 p300 的小分子激活剂。CTB 是 CTPB 的一种简化类似物，具有相当或更高的活性。该化合物激活 p300/EP300/E1A 结合蛋白的组蛋白乙酰转移酶 (HAT) 活性。
CBP（CREB 结合蛋白）/p300）组蛋白乙酰转移酶 (HAT) 激活剂；p300 HAT 激活器。
Features and Benefits
这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
存储类别
11 - Combustible Solids
wgk
WGK 2
商品
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C6499-25MG | 04061832631868 |
| C6499-5MG | 04061832631875 |