C6506
4-氯-DL-苯丙氨酸
5-HT synthesis inhibitor, solid
别名:
PCP, PCPA
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
线性分子式:
ClC6H4CH2CH(NH2)CO2H
化学文摘社编号:
分子量:
199.63
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
231-051-9
MDL number:
产品名称
4-氯-DL-苯丙氨酸,
form
solid
Quality Level
greener alternative product score
old score: 2
new score: 1
Find out more about DOZN™ Scoring
greener alternative product characteristics
Less Hazardous Chemical Syntheses
Designing Safer Chemicals
Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.
sustainability
Greener Alternative Product
mp
>240 °C (dec.) (lit.)
greener alternative category
storage temp.
room temp
SMILES string
NC(Cc1ccc(Cl)cc1)C(O)=O
InChI
1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
InChI key
NIGWMJHCCYYCSF-UHFFFAOYSA-N
Gene Information
human ... TPH1(7166), TPH2(121278)
General description
我们竭诚为您带来满足绿色替代产品四大类别要求的替代产品。本品属于重新设计产品类别，在“危险性较小的化学合成”、“设计更安全的化学品和产品”和“节能设计”绿色化学原则方面取得了重大改进。 点击此处查看其 DOZN 记分卡。
Application
4-氯-DL-苯丙氨酸用于：
- 作为色氨酸羟化酶1（TPH1）抑制剂，处理 kras+ 雄性斑马鱼
- 在大鼠模型中诱发失眠
- 处理胚胎，检查其对5-羟色胺的影响
- 选择带 pESentA32质粒的粪肠球菌（ Enterococcus faecalis ）转化体
- 饲喂苍蝇，研究5-羟色胺的作用
Biochem/physiol Actions
4-氯-DL-苯丙氨酸（PCPA）是5-羟色胺（5-HT）合成抑制剂。有助于改善肺部组织炎症和重塑肺动脉。PCPA 可减少色氨酸羟化酶1（TPH1）、基质金属蛋白酶（MMP）和促炎因子的表达。
色氨酸羟化酶抑制剂。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Skin Sens. 1
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Kristoffer Sahlholm et al.
Frontiers in pharmacology, 9, 338-338 (2018-04-26)
Pridopidine is in clinical trials for Huntington's disease treatment. Originally developed as a dopamine D2 receptor (D2R) ligand, pridopidine displays about 100-fold higher affinity for the sigma-1 receptor (sigma-1R). Interestingly, pridopidine slows disease progression and improves motor function in Huntington's
Jianxiang Chen et al.
Experimental biology and medicine (Maywood, N.J.), 242(11), 1142-1149 (2017-04-22)
Hepatocellular carcinoma is one of the most common causes of cancer-related death worldwide. Hepatocellular carcinoma development depends on the inhibition and activation of multiple vital pathways, including the Wnt signaling pathway. The Wnt/β-catenin pathway lies at the center of various
Serotonin activated hepatic stellate cells contribute to sex disparity in hepatocellular carcinoma
Yang Q, et al.
Cellular and molecular gastroenterology and hepatology, 3(3), 484-499 (2017)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C6506-25G | 04061833618899 |
| C6506-5G | 04061833511305 |