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C6734

CAY10397

Name: CAY10397
Brand: SIGMA

solid, >98%

别名:

5-[[4-(Ethoxycarbonyl)phenyl]azo]-2-hydroxybenzeneacetic acid, CK47A

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关于此项目

经验公式（希尔记法）:

C₁₇H₁₆N₂O₅

化学文摘社编号:

78028-01-0

分子量:

328.32

UNSPSC Code:

12352200

PubChem Substance ID:

329775130

NACRES:

NA.77

MDL number:

MFCD03412024

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属性

产品名称

CAY10397, >98%, solid

Quality Level

200

assay

>98%

form

solid

shipped in

wet ice

storage temp.

−20°C

SMILES string

CCOC(=O)c1ccc(cc1)\N=N\c2ccc(O)c(CC(O)=O)c2

InChI

1S/C17H16N2O5/c1-2-24-17(23)11-3-5-13(6-4-11)18-19-14-7-8-15(20)12(9-14)10-16(21)22/h3-9,20H,2,10H2,1H3,(H,21,22)/b19-18+

InChI key

YYBSDOZYJSGLTH-VHEBQXMUSA-N

说明

Biochem/physiol Actions

Potent and selective inhibitor of 15-hydroxyprostaglandin dehydrogenase (15-hydroxy-PGDH). Acts to prolong the lifetime and activity of endogenously produced prostaglandins both in vitro and in vivo.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

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Possible predisposition for colorectal carcinogenesis due to altered gene expressions in normal appearing mucosa from patients with colorectal neoplasia.

Christian Hunnicke Petersen et al.

BMC cancer, 19(1), 643-643 (2019-06-30)

Investigations of colorectal carcinogenesis have mainly focused on examining neoplastic tissue. With our aim of identifying potentially cancer-predisposing molecular compositions, we chose a different approach by examining endoscopically normal appearing colonic mucosa of patients with and without colorectal neoplasia (CRN).

The Essential Role of Selenoproteins in the Resolution of Citrobacter rodentium-Induced Intestinal Inflammation.

Shaneice K Nettleford et al.

Frontiers in nutrition, 7, 96-96 (2020-08-11)

Enteropathogenic Escherichia coli (EPEC) leads to adverse colonic inflammation associated with poor resolution of inflammation and loss of epithelial integrity. Micronutrient trace element selenium (Se) is incorporated into selenoproteins as the 21st amino acid, selenocysteine (Sec). Previous studies have shown

15-PGDH/15-KETE plays a role in hypoxia-induced pulmonary vascular remodeling through ERK1/2-dependent PAR-2 pathway.

Liuping Wei et al.

Cellular signalling, 26(7), 1476-1488 (2014-03-25)

We have established that 15-hydroxyeicosatetraenoic acid is an important factor in regulation of pulmonary vascular remodeling (PVR) associated with hypoxia-induced pulmonary hypertension (PH), which is further metabolized by 15-hydroxyprostaglandin dehydrogenase (15-PGDH) to form 15-ketoeicosatetraenoic acid (15-KETE). However, the role of

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C6734-1MG	04061826674215