主要文件

查看所有文档

C7081

WY-14643

Name: WY-14643
Brand: SIGMA

Selective PPARα agonist, powder

别名:

4-氯-6-（2,3-二甲苯基）-2-嘧啶硫代乙酸, 匹立尼酸（降血脂药）

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₁₄H₁₄ClN₃O₂S

化学文摘社编号:

50892-23-4

分子量:

323.80

UNSPSC Code:

12352200

PubChem Substance ID:

24892928

NACRES:

NA.77

MDL number:

MFCD00191335

Form:

powder

Quality level:

100

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

产品名称

WY-14643,

form

powder

Quality Level

100

SMILES string

CC1=C(C)C=CC=C1NC2=NC(SCC(O)=O)=NC(Cl)=C2

InChI

1S/C14H14ClN3O2S/c1-8-4-3-5-10(9(8)2)16-12-6-11(15)17-14(18-12)21-7-13(19)20/h3-6H,7H2,1-2H3,(H,19,20)(H,16,17,18)

InChI key

SZRPDCCEHVWOJX-UHFFFAOYSA-N

Gene Information

human ... PPARA(5465), PPARD(5467), PPARG(5468)
mouse ... Ppara(19013)
rat ... Ppara(25747)

说明

General description

WY-14643 可防止脂多糖 (LPS) 诱导的滑膜成纤维细胞炎症。它能保护皮质神经元免受促炎介质诱导的细胞损伤。WY-14643 对小胶质细胞的促炎反应有抑制作用。它能改善疾病模型中的氧化-亚硝化应激，减少大脑中活性氧 (ROS)、一氧化氮 (NO) 和脂质过氧化终产物的生成。

Application

WY-14643 已被用于：

作为转染和荧光素酶检测的阳性对照
，刺激骨髓源性巨噬细胞 (BMDM) 进行自噬通量分析
，以分析细胞培养物中脂肪酸代谢-免疫联系 (FAMIN) 表达的调节

Biochem/physiol Actions

选择性 PPARα激动剂。

Features and Benefits

该化合物是受体分类及信号转导手册上核受体（非类固醇）和核受体(PPARs)页面上的推荐化合物。想要浏览手册的其他页面，请单击此处。

pictograms

GHS08,GHS07

signalword

Danger

hcodes

H302,H315,H319,H335,H350

pcodes

P201 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Tumor necrosis factor α stimulates endogenous apolipoprotein A-I expression and secretion by human monocytes and macrophages: role of MAP-kinases, NF-κB, and nuclear receptors PPARα and LXRs.

Vladimir S Shavva et al.

Molecular and cellular biochemistry, 448(1-2), 211-223 (2018-02-15)

Apolipoprotein A-I (ApoA-I) is the main structural and functional protein component of high-density lipoprotein. ApoA-I has been shown to regulate lipid metabolism and inflammation in macrophages. Recently, we found the moderate expression of endogenous apoA-I in human monocytes and macrophages

PPARα regulates cholinergic-driven activity of midbrain dopamine neurons via a novel mechanism involving α7 nicotinic acetylcholine receptors.

Miriam Melis et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(14), 6203-6211 (2013-04-05)

Ventral tegmental area dopamine neurons control reward-driven learning, and their dysregulation can lead to psychiatric disorders. Tonic and phasic activity of these dopaminergic neurons depends on cholinergic tone and activation of nicotinic acetylcholine receptors (nAChRs), particularly those containing the β2

Nuclear receptors agonists exert opposing effects on the inflammation dependent survival of breast cancer stem cells.

A Papi et al.

Cell death and differentiation, 19(7), 1208-1219 (2012-01-21)

Recent literature highlights the importance of pro-inflammatory cytokines in the biology of breast cancer stem cells (CSCs), unraveling differences with respect to their normal counterparts. Expansion of mammospheres (MS) is a valuable tool for the in vitro study of normal

查看所有相关文献

全球贸易项目编号

货号	GTIN
C7081-10MG	04061833511879
C7081-50MG	04061832954219