C7521
Human Collagen Type IV
from human placenta, powder, suitable for substrate for collagenase and for diagnostic assay manufacturing
别名:
4型胶原蛋白
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关于此项目
Biological source:
human placenta
产品名称
胶原蛋白 来源于人类胎盘, Bornstein and Traub Type IV, powder
biological source
human placenta
Quality Level
description
Sigma Type VI
form
powder
impurities
HIV, hepatitis B and hepatitis C, none detected
solubility
0.5 M acetic acid: 1 mg/mL
suitability
suitable for substrate for collagenase
application(s)
diagnostic assay manufacturing
storage temp.
−20°C
Gene Information
human ... COL4A2(1284), COL4A3(1285), COL4A4(1286), COL4A5(1287), COL4A6(1288)
Biochem/physiol Actions
在发育过程中，胶原蛋白IV普遍分布在BM中。 在成熟过程中，该网状纤维以显著的组织特异性方式被部分替换，从而定义BM结构和功能。 胶原蛋白IV可以结合血小板、肝细胞、角质形成细胞、内皮细胞、肾小球膜细胞、胰腺细胞以及一些肿瘤细胞。
Preparation Note
本品为冻干粉末，能够以1 mg/mL的浓度重悬于无菌的.5 M乙酸、PBS或水中。 PBS能够在-20℃情况下稳定保存至少一年。它是通过改良版 Glanville, R.W., et al胃蛋白酶提取蛋白制备的。
Analysis Note
SDS聚丙烯酰胺凝胶电泳在和基底膜胶原蛋白相同的还原条件下测试，得到三条主要条带。
Other Notes
胶原蛋白被分为许多种结构和遗传性不同的类型。 我们使用 Bornstein和Traub提出的系统命名法。 小心不要混淆Sigma命名系统和通用的胶原蛋白分类类型。
所有胶原蛋白分子均由以三螺旋构象排列的三条肽链组成，其一级结构主要以三个氨基酸作为重复基序，即每隔两个氨基酸是一个甘氨酸残基，其前面的两个位置通常为脯氨酸或4-羟基脯氨酸。 IV型胶原仅存在于基底膜中，并含有多达六条基因不同的a链。
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存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Marion Jeanne et al.
Circulation, 131(18), 1555-1565 (2015-03-11)
Collagen type IV alpha1 (COL4A1) and alpha2 (COL4A2) form heterotrimers critical for vascular basement membrane stability and function. Patients with COL4A1 or COL4A2 mutations suffer from diverse cerebrovascular diseases, including cerebral microbleeds, porencephaly, and fatal intracerebral hemorrhage (ICH). However, the
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C7521-5MG | 04061833512708 |
| C7521-10MG | 04061833512678 |
| C7521-50MG | 04061833512685 |