C7897
可乐定 盐酸盐
α2-adrenoceptor agonist, solid
别名:
[2-(2,6-二氯苯基)亚氨基]咪唑烷 盐酸盐
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关于此项目
经验公式（希尔记法）:
C9H9Cl2N3 · HCl
化学文摘社编号:
分子量:
266.55
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
224-121-5
MDL number:
Beilstein/REAXYS Number:
4163525
Form:
solid
Quality level:
产品名称
可乐定 盐酸盐, solid
form
solid
Quality Level
color
white
solubility
H2O: soluble, methanol: soluble
originator
Boehringer Ingelheim
storage temp.
2-8°C
SMILES string
Cl[H].Clc1cccc(Cl)c1NC2=NCCN2
InChI
1S/C9H9Cl2N3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9;/h1-3H,4-5H2,(H2,12,13,14);1H
InChI key
ZNIFSRGNXRYGHF-UHFFFAOYSA-N
Gene Information
human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)
General description
盐酸可乐定具有降压、止痛和止泻特性。它在体外，可降低短路电流，阻止阴离子的分泌，并改善粘膜对液体和电解质的吸收。可乐定可用于治疗注意力不足和多动症（ADHD）、更年期潮红、撤药综合征和Tourette′s综合征。
Application
可乐定盐酸盐已被用于：
- 降低中央去甲肾上腺素水平
- 抑制异硫氰酸烯丙酯（AITC）敏化的热厌恶
- 减轻大鼠的热和机械性疼痛超敏反应
- 作为百日咳毒素（PTX）的阳性对照
盐酸可乐定已作为肾上腺素能受体（ADRA2A）激动剂用于：
- 离体 瘦素释放测定
- 研究其对6-OHDA损伤大鼠疼痛超敏反应的影响
- 研究其对幼虫斑马鱼睡眠的影响
- 操纵去甲肾上腺素并检查其对行为灵活性和动机的影响
Biochem/physiol Actions
盐酸可乐定可用于治疗孕妇的高血压。此外，它还可以作为新生儿戒断综合征的治疗剂。盐酸可乐定可与α-肾上腺素能受体的中心结合，并降低心脏、肾脏和周围脉管系统的交感神经元血管收缩压，从而导致血管舒张和血压降低。
α2-肾上腺素能受体激动剂；I1 咪唑啉结合位点配体。
Features and Benefits
该化合物由 Boehringer Ingelheim 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单，请单击此处。
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 3 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Safety and efficacy of clonidine and clonidine extended-release in the treatment of children and adolescents with attention deficit and hyperactivity disorders
Ming X, et al.
Adolescent health, medicine and therapeutics, 2(2), 105-105 (2011)
INT-005 Development and stability testing of oral clonidine hydrochloride solutions for use in neonatal patients
Buttner B, et al.
European Journal of Hospital Pharmacy (2017)
Z P Khan et al.
Anaesthesia, 54(2), 146-165 (1999-04-24)
Clonidine has proved to be a clinically useful adjunct in clinical anaesthetic practice as well as in chronic pain therapy because it has both anaesthetic and analgesic-sparing activity. The more selective alpha-2 adrenoceptor agonists, dexmedetomidine and mivazerol, may also have
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C7897-250MG | 04061833521311 |
| C7897-5G | 04061833521328 |
| C7897-100MG | 04061833521304 |
| C7897-1G | 04061825982120 |