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C8221

咖啡酸苯乙酯

Name: 咖啡酸苯乙酯
Brand: SIGMA

synthetic, ≥97% (HPLC), Nuclear transcription factor NF-κB inhibitor, powder

别名:

CAPE

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关于此项目

经验公式（希尔记法）:

C₁₇H₁₆O₄

化学文摘社编号:

104594-70-9

分子量:

284.31

UNSPSC Code:

12352108

PubChem Substance ID:

24278341

NACRES:

NA.77

MDL number:

MFCD00866470

Assay:

≥97% (HPLC)

Form:

powder

Quality level:

200

Storage condition:

protect from light

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属性

产品名称

咖啡酸苯乙酯, ≥97% (HPLC), powder

biological source

synthetic

Quality Level

200

assay

≥97% (HPLC)

form

powder

storage condition

protect from light

color

off-white

solubility

ethyl acetate: 50 mg/mL, DMSO: soluble, ethanol: soluble

storage temp.

−20°C

SMILES string

Oc1ccc(\C=C\C(=O)OCCc2ccccc2)cc1O

InChI

1S/C17H16O4/c18-15-8-6-14(12-16(15)19)7-9-17(20)21-11-10-13-4-2-1-3-5-13/h1-9,12,18-19H,10-11H2/b9-7+

InChI key

SWUARLUWKZWEBQ-VQHVLOKHSA-N

Gene Information

human ... NFKB2(4791)

说明

Application

咖啡酸苯乙酯(CAPE)已用于测定CAPE对甲亢的作用，作为培养基组分检测乳腺癌细胞系MDA-MB-231的细胞毒性，研究其对大鼠胺碘酮诱导肺纤维化的影响。

Biochem/physiol Actions

CAPE具有多种特性，如抗癌、免疫调节活性、抗氧化、抗病毒、抗炎、降血糖作用、心脏保护功能以及胃分泌抑制作用。它还对一种乳腺癌肿瘤生长因子——成纤维细胞生长因子2(FGF-2)具有抑制作用。

咖啡酸苯乙酯是核转录因子 NF-κ B的特异性抑制剂。

Features and Benefits

该化合物是基因调控研究的特色产品。点击此处，发现更多特色基因调控产品。在 sigma.com/discover-bsm 了解更多关于其他研究领域的生物活性小分子。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

NF-κB and Inflammation

Chronic inflammation is an underlying factor in the development and progression of many of the chronic diseases of aging, such as arthritis, atherosclerosis, diabetes, and cancer.

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Apoptosis mediates the selective toxicity of caffeic acid phenethyl ester (CAPE) toward oncogene-transformed rat embryo fibroblast cells.

Z Z Su et al.

Anticancer research, 15(5B), 1841-1848 (1995-09-01)

The active component of the folk medicine propolis, caffeic acid phenethyl ester (CAPE), displays selective toxicity toward cloned rat embryo fibroblast (CREF) cells transformed by a spectrum of diverse acting oncogenes. Identification of the mode of action of CAPE should

Strategies for elevating hematopoietic stem cells expansion and engraftment capacity.

Mehdi Derakhshani et al.

Life sciences, 232, 116598-116598 (2019-06-28)

Hematopoietic stem cells (HSCs) are a rare cell population in adult bone marrow, mobilized peripheral blood, and umbilical cord blood possessing self-renewal and differentiation capability into a full spectrum of blood cells. Bone marrow HSC transplantation has been considered as

Protective effect of caffeic acid phenethyl ester (CAPE) on amiodarone-induced pulmonary fibrosisin rat

Zaeemzadeh N, et al.

Iranian Journal of Pharmaceutical Research : IJPR, 10(2), 321-321 (2011)

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全球贸易项目编号

货号	GTIN
C8221-1G	04061833521922