C8739
Cyclin-Dependent Kinase 5 human
recombinant, expressed in E. coli BL21, 50-100 units/μg protein
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关于此项目
Specific activity:
50-100 units/μg protein
Recombinant:
expressed in E. coli BL21
recombinant
expressed in E. coli BL21
Quality Level
form
solution
specific activity
50-100 units/μg protein
packaging
vial of 300 units
shipped in
dry ice
storage temp.
−70°C
Application
Human cyclin-dependent kinase 5 has been used in a study to determine its 3′ untranslated region subunit 1 contains regulatory elements that affect transcript stability.
Biochem/physiol Actions
CDK5 is highly expressed in the nervous system where it phosphorylates a multitude of substrates. CDK5 plays an important role in many processes such as: apoptosis, phototransduction, dopamine and glutamate signalling, neurite outgrowth, neurone migration, induction of acetylcholine receptors, golgi membrane traffic and insulin exocytosis. It has also been implicated in the pathogenesis of amyotrophic lateral sclerosis . It is activated by p35 and p39, and their proteolytic cleavage products, p25 and p29.
Physical form
Supplied as a solution in PBS pH 7.4, 1 mM EDTA, 1mM DTT and 1 mg/ml BSA
Other Notes
One unit will phosphorylate 1.0 picomole of the peptide substrate histone H19-18 per minute at 30 °C at pH 7.4.
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Kwok-On Lai et al.
The Journal of biological chemistry, 290(23), 14637-14646 (2015-04-24)
The maturation and maintenance of dendritic spines depends on neuronal activity and protein synthesis. One potential mechanism involves mammalian target of rapamycin, which promotes protein synthesis through phosphorylation of eIF4E-binding protein and p70 ribosomal S6 kinase 1 (S6K). Upon extracellular
Pharmacological inhibitors of cyclin-dependent kinases
Knockaert M, et al.
Trends in Pharmacological Sciences, 23(9), 417-425 (200)
Silvia Moncini et al.
BMC molecular biology, 8, 111-111 (2007-12-07)
CDK5R1 plays a central role in neuronal migration and differentiation during central nervous system development. CDK5R1 has been implicated in neurodegenerative disorders and proposed as a candidate gene for mental retardation. The remarkable size of CDK5R1 3'-untranslated region (3'-UTR) suggests
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C8739-1VL | 04061822429529 |