C8988
8-（4-氯苯硫基）-2′-O-甲基腺苷- 3′,5′-环一磷酸 单钠 水合物
≥98% (HPLC), Epac or cAMP-GEF activator, powder
别名:
8-pCPT-2′-O-Me-cAMP
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C17H16N5O6ClPSNa · xH2O
化学文摘社编号:
分子量:
507.82 (anhydrous basis)
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
8-（4-氯苯硫基）-2′-O-甲基腺苷- 3′,5′-环一磷酸 单钠 水合物, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
white
mp
235.5-237.5 °C (lit.)
solubility
H2O: >10 mg/mL
storage temp.
−20°C
SMILES string
O.[Na+].CO[C@@H]1[C@@H]2OP([O-])(=O)OC[C@H]2O[C@H]1n3c(Sc4ccc(Cl)cc4)nc5c(N)ncnc35
InChI
1S/C17H17ClN5O6PS.Na.H2O/c1-26-13-12-10(6-27-30(24,25)29-12)28-16(13)23-15-11(14(19)20-7-21-15)22-17(23)31-9-4-2-8(18)3-5-9;;/h2-5,7,10,12-13,16H,6H2,1H3,(H,24,25)(H2,19,20,21);;1H2/q;+1;/p-1/t10-,12-,13-,16-;;/m1../s1
InChI key
NVPSOXGMFVFZIS-IPBMGFFTSA-M
Biochem/physiol Actions
天然cAMP的类似物，Epac或cAMP-GEF的强效和特异性膜透过活化剂，是环磷酸腺苷的一种新受体。
天然cAMP的类似物，由cAMP（Epac或cAMP-GEF）直接激活的交换因子的强效和特异性膜透过活化剂，是环磷酸腺苷的一种新受体
Features and Benefits
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
Other Notes
光敏感
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
Andrzej J Chruscinski et al.
PloS one, 8(12), e82164-e82164 (2013-12-18)
β-adrenergic receptors (β-ARs) are model G-protein coupled receptors that mediate signal transduction in the sympathetic nervous system. Despite the widespread clinical use of agents that target β-ARs, the signaling pathways that operate downstream of β-AR stimulation have not yet been
Ángeles Domínguez-Soto et al.
Scientific reports, 7(1), 14761-14761 (2017-11-09)
Peripheral serotonin (5-hydroxytryptamine, 5-HT) regulates cell growth and differentiation in numerous cell types through engagement of seven types of cell surface receptors (HTR1-7). Deregulated 5-HT/HTR levels contribute to pathology in chronic inflammatory diseases, with macrophages being relevant targets for the
Mengye Li et al.
Clinical and experimental pharmacology & physiology, 44(6), 686-692 (2017-03-21)
Recent papers have attributed arrhythmic substrate in murine RyR2-P2328S hearts to reduced action potential (AP) conduction velocities (CV), reflecting acute functional inhibition and/or reduced expression of sodium channels. We explored for acute effects of direct exchange protein directly activated by
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C8988-1MG | 04061833523094 |
| C8988-5MG | 04061832897721 |