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C8999

Calpeptin

Name: Calpeptin
Brand: SIGMA

≥98% (HPLC), calpain inhibitor, powder

别名:

N-苄氧羰基-L-亮氨酰基核, Z-Leu-Nle-CHO

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关于此项目

经验公式（希尔记法）:

C₂₀H₃₀N₂O₄

化学文摘社编号:

117591-20-5

分子量:

362.46

UNSPSC Code:

12352200

PubChem Substance ID:

329775192

NACRES:

NA.77

MDL number:

MFCD00155623

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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属性

产品名称

Calpeptin, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 15 mg/mL, clear

shipped in

wet ice

storage temp.

−20°C

SMILES string

CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=O

InChI

1S/C20H30N2O4/c1-4-5-11-17(13-23)21-19(24)18(12-15(2)3)22-20(25)26-14-16-9-7-6-8-10-16/h6-10,13,15,17-18H,4-5,11-12,14H2,1-3H3,(H,21,24)(H,22,25)/t17-,18-/m0/s1

InChI key

PGGUOGKHUUUWAF-ROUUACIJSA-N

说明

General description

Calpeptin (Z-Leu-nLeu-H) 是一种具有细胞渗透性的肽醛抑制剂。与其他抑制剂，如 Z-Leu-Met-H 和 leupeptin 相比，它对钙蛋白酶 I 更敏感。Calpeptin 刺激分化的嗜铬细胞瘤 (PC12) 细胞的神经突延长。Calpeptin 减少实验性自身免疫性脑脊髓炎 (EAE) 脊髓的小胶质细胞增生、星形胶质细胞增生、轴突损伤以及神经元和少突胶质细胞死亡。因此，可以认为它是治疗 EAE 和多发性硬化 (MS) 的强效治疗药物。

Application

Calpeptin 已被用作钙蛋白酶抑制剂。

Biochem/physiol Actions

Calpeptin 是 rho 激酶激活剂和钙蛋白酶抑制剂，钙蛋白酶是钙依赖性半胱氨酸蛋白酶家族，参与细胞凋亡、神经元的长时程增强和细胞周期进程。

Calpeptin 是一种钙蛋白酶抑制剂和 rho 激酶激活剂。

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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High fidelity neuronal networks formed by plasma masking with a bilayer membrane: analysis of neurodegenerative and neuroprotective processes.

Heike Hardelauf et al.

Lab on a chip, 11(16), 2763-2771 (2011-06-29)

Spatially defined neuronal networks have great potential to be used in a wide spectrum of neurobiology assays. We present an original technique for the precise and reproducible formation of neuronal networks. A PDMS membrane comprising through-holes aligned with interconnecting microchannels

Calpeptin, a calpain inhibitor, promotes neurite elongation in differentiating PC12 cells.

Pinter M, et al.

Neuroscience Letters, 170(1), 91-93 (1994)

Demethylation and re-expression of epigenetically silenced tumor suppressor genes: sensitization of cancer cells by combination therapy.

Sibaji Sarkar et al.

Epigenomics, 5(1), 87-94 (2013-02-19)

Epigenetic regulation in eukaryotic and mammalian systems is a complex and emerging field of study. While histone modifications create an open chromatin conformation allowing for gene transcription, CpG methylation adds a further dimension to the expression of specific genes in

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货号	GTIN
C8999-25MG	04061833218242
C8999-5MG	04061833523100