C9282
胆酸钠 水合物
suitable for cell culture, BioReagent
别名:
3α,7α,12α-三羟基-5β-胆甾烷-24-羧酸 钠盐, 胆酸 钠盐
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关于此项目
经验公式（希尔记法）:
C24H39NaO5 · xH2O
化学文摘社编号:
分子量:
430.55 (anhydrous basis)
UNSPSC Code:
12161902
NACRES:
NA.75
PubChem Substance ID:
EC Number:
206-643-5
Beilstein/REAXYS Number:
3582354
MDL number:
Quality Level
biological source
bovine bile, ovine bile
description
anionic
product line
BioReagent
assay
≥99.0% (HPLC)
form
powder
mol wt
micellar avg mol wt 900-1300
aggregation number
2-3
technique(s)
cell culture | mammalian: suitable
CMC
9-15 mM (20-25°C)
solubility
water: 100 mg/mL, clear, colorless to light yellow
HLB
18
SMILES string
O.[Na+].C[C@H](CCC([O-])=O)C1CCC2C3[C@H](O)CC4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C
InChI
1S/C24H40O5.Na.H2O/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26;;/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29);;1H2/q;+1;/p-1/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-;;/m1../s1
InChI key
MUVVIYFKOVLQHL-RCVKHMDESA-M
General description
胆酸盐是由肝脏中的胆固醇产生的初级胆汁酸。它是在固醇12α-羟化酶（CYP8B1）存在的情况下由胆固醇合成的一种阴离子洗涤剂。
Application
胆酸盐是肝脏在胆固醇分解过程中产生的一种胆酸。胆酸盐向下调节胆固醇-7α-羟化酶（胆汁酸合成中的限速步骤）。 胆酸盐是一种阴离子洗涤剂，可单独使用或与尿素一起使用，用于提取和重建膜蛋白和蛋白复合物。
胆酸钠水合物已被用于：
- 作为胆汁酸用于诱导胆汁酸响应（BEAR）转录系统,
- 作为弯曲杆菌确定成分肉汤（CDB）的成分用于测试其对空肠弯曲杆菌i{52应激反应的影响
- 测试其对胆汁酸传感器的敏感性
Biochem/physiol Actions
12-α羟化酶活性的下降会导致肝脏疾病患者中胆酸水平降低。
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hcodes
pcodes
Hazard Classifications
Aquatic Chronic 3
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Proteome Profiling by Label-Free Mass Spectrometry Reveals Differentiated Response of Campylobacter jejuni 81-176 to Sublethal Concentrations of Bile Acids
Masanta WO, et al.
Proteomics. Clinical Applications, 13(3), 1800083-1800083 (2019)
John Y L Chiang
Journal of lipid research, 50(10), 1955-1966 (2009-04-07)
Bile acids are physiological detergents that generate bile flow and facilitate intestinal absorption and transport of lipids, nutrients, and vitamins. Bile acids also are signaling molecules and inflammatory agents that rapidly activate nuclear receptors and cell signaling pathways that regulate
A Ambesi et al.
Analytical biochemistry, 198(2), 312-317 (1991-11-01)
Solubilization and reconstitution of the cardiac sarcolemmal Na+/Ca2+ exchanger by use of the anionic detergent cholate and its application for reconstitution of the exchanger following solubilization with zwitterionic or nonionic detergents is described. Solubilization and reconstitution with cholate provided a
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C9282-100G | 04061833530481 |
| C9282-25G | 04061833530498 |