C9521
Z-Phe-Arg 7-酰氨基-4-甲基香豆素 盐酸盐
kallikrein substrate, ≥95% (HPLC), powder
别名:
Z-Phe-Arg-AMC
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关于此项目
经验公式（希尔记法）:
C33H36N6O6 · HCl
化学文摘社编号:
分子量:
649.14
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32
MDL number:
产品名称
Z-Phe-Arg 7-酰氨基-4-甲基香豆素 盐酸盐, kallikrein substrate
Quality Level
assay
≥95% (HPLC)
form
powder
concentration
≥95%
solubility
methanol: 20 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(NC2=CC=C(C(C)=CC(O3)=O)C3=C2)=O)=O)OCC4=CC=CC=C4.[Cl]
InChI
1S/C33H36N6O6/c1-21-17-29(40)45-28-19-24(14-15-25(21)28)37-30(41)26(13-8-16-36-32(34)35)38-31(42)27(18-22-9-4-2-5-10-22)39-33(43)44-20-23-11-6-3-7-12-23/h2-7,9-12,14-15,17,19,26-27H,8,13,16,18,20H2,1H3,(H,37,41)(H,38,42)(H,39,43)(H4,34,35,36)
InChI key
ZZGDDBWFXDMARY-UHFFFAOYSA-N
General description
Z-苯丙氨酸-精氨酸 7-氨基-4-甲基香豆素(Z-FR-AMC）是一种拟肽类底物，可用于木瓜蛋白酶和其它酶，如组织蛋白酶K。它也是组织蛋白酶L和B的荧光合成肽。
一种用于血浆激肽释放酶的荧光底物。
Application
Z-苯丙氨酸-精氨酸7-氨基-4-甲基香豆盐酸盐已被用于：
- 作为猕猴桃碱抑制检测中的荧光底物
- 作为血管舒缓素底物
- 作为荧光检测的胰蛋白酶底物
- 作为组织蛋白酶-L底物
Biochem/physiol Actions
由蛋白酶引发的Z-苯丙氨酸-精氨酸7-氨基-4-甲基香豆素（Z-FR-AMC）的蛋白水解性裂解导致AMC的释放，结果使酶反应中的荧光增强。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
L Troeberg et al.
Immunopharmacology, 36(2-3), 295-303 (1997-06-01)
Anti-peptide antibodies were produced against the cysteine proteinase trypanopain-Tb from Trypanosoma brucei brucei and the effects of these antibodies on enzyme activity against carboxybenzoyl (Z)-Phe-Arg-aminomethylcoumarin (AMC) investigated. A peptide was synthesised corresponding to a region of the trypanopain-Tb active site
L Salvati et al.
European journal of biochemistry, 268(11), 3253-3258 (2001-06-08)
Cysteine proteinases are relevant to several aspects of the parasite life cycle and of parasite-host relationships. Here, a quantitative investigation of the effect of temperature and pH on the total substrate inhibition of cruzipain, the major papain-like cysteine proteinase from
Early ontogenetic development, digestive enzymatic activity and gene expression in red sea bream (Pagrus major)
Khoa TND, et al.
Aquaculture (Amsterdam, Netherlands), 512, 734283-734283 (2019)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C9521-100MG | 04061832908281 |
| C9521-25MG | 04061833530801 |