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CNSBR004

卡那霉素硫酸酯来源于卡那霉素链霉菌

Name: 卡那霉素 硫酸酯 来源于<I>卡那霉素链霉菌</I>
Brand: SIGMA

potency: ≥765 μg Kanamycin base/mg (dry basis), powder

别名:

卡那霉素 A, 卡那霉素碱硫酸盐

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关于此项目

经验公式（希尔记法）:

C₁₈H₃₆N₄O₁₁ · H₂O₄S

化学文摘社编号:

25389-94-0

分子量:

582.58

UNSPSC Code:

51101500

MDL number:

MFCD00070253

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属性

form

powder

Quality Level

200

potency

≥765 μg Kanamycin base/mg (dry basis)

color

white to off-white

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycobacteria, mycoplasma

mode of action

protein synthesis | interferes

SMILES string

OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1

InChI key

OOYGSFOGFJDDHP-KMCOLRRFSA-N

说明

General description

Chemical structure: aminoglycoside

Kanamycin sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus. It is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 100μg/mL.

Application

Kanamycin sulfate from Streptomyces kanamyceticus has been used in tissue culture media.

Biochem/physiol Actions

作用机制：该产品通过与70S核糖体亚基结合，抑制易位并引起错误编码而起作用。

耐药机制：氨基糖苷类修饰酶（包括乙酰转移酶、磷酸转移酶、核苷酸转移酶）可以改变这种抗生素，阻止其与核糖体相互作用。

抗菌谱：硫酸卡那霉素对革兰氏阴性和革兰氏阳性菌以及支原体有效。

Features and Benefits

High quality antibiotic suitable for mulitple research applications.

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pictograms

GHS08

signalword

Danger

hcodes

H360D

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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全球贸易项目编号

货号	GTIN
CNSBR004-1G	04065272679893