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Merck
CN

CNSBR009

氨苄西林 钠盐

potency: 845-988 μg per mg, powder

别名:

氨苄青霉素 钠盐

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关于此项目

经验公式(希尔记法):
C16H18N3NaO4S
化学文摘社编号:
分子量:
371.39
UNSPSC Code:
51101500
Beilstein/REAXYS Number:
4119211
MDL number:
Form:
powder
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form

powder

Quality Level

potency

845-988 μg per mg

color

white to off-white

mp

215 °C (dec.) (lit.)

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

SMILES string

[Na+].CC1(C)SC2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C([O-])=O

InChI

1S/C16H19N3O4S.Na/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);/q;+1/p-1/t9-,10-,11+,14-;/m1./s1

InChI key

KLOHDWPABZXLGI-YWUHCJSESA-M

General description

Ampicillin sodium salt is a member of the extended-spectrum β-lactam family and a semisynthetic derivative of penicillin that functions as a broad-spectrum antibiotic. It is a β-lactam antibiotic that inhibits bacterial cell-wall synthesis by binding to penicillin-binding proteins (PBPs), thereby inhibiting peptidoglycan synthesis, a critical component of the bacterial cell wall. Ampicillin sodium salt is active against a wide range of Gram-positive and Gram-negative bacteria, including E.coli, β-lactam-sensitive VRE, vancomycin-resistant Enterococcus species, Staphylococcus aureus, and Streptococcus pneumoniae. It is commonly used in research laboratories to study antibiotic resistance and penetration limitations, the synergy between multiple antibiotics, and the selection and maintenance of recombinant plasmids in E.coli.

Application

Ampicillin sodium salt has been used:
- to select for ampicillin resistance in mutated and transformed cells

Biochem/physiol Actions

作用方式:该β-内酰胺抗生素通过灭活位于细菌的细胞膜内表面的转肽酶从而抑制细菌细胞壁合成。

耐药性机制:β-内酰胺酶切开氨苄青霉素的β-内酰胺环,使其失去活性。

抗菌谱:包括革兰氏阳性菌(类似青霉素)和革兰氏阴性菌(类似四环素和氯霉素)。

Features and Benefits

High quality antibiotic suitable for mulitple research applications.


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pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Resp. Sens. 1A - Skin Sens. 1A

存储类别

11 - Combustible Solids

wgk

WGK 3

法规信息

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全球贸易项目编号

货号GTIN
CNSBR009-50G04065272682046