主要文件

查看所有文档

D052

GBR 12909 二盐酸盐

Name: GBR 12909 二盐酸盐
Brand: SIGMA

≥98% (HPLC), dopamine transportef nhibitor, solid

别名:

1-（2-[双（4-氟苯基）甲氧基]乙基）-4-（3-苯丙基）哌嗪二盐酸盐

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₂₈H₃₂F₂N₂O · 2HCl

化学文摘社编号:

67469-78-7

分子量:

523.49

UNSPSC Code:

12352200

PubChem Substance ID:

24277909

NACRES:

NA.77

MDL number:

MFCD00055193

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

desiccated

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

产品名称

GBR 12909 二盐酸盐, solid, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white

solubility

DMSO: >5 mg/mL (Solutions freshly prepared daily)

SMILES string

Cl.Cl.Fc1ccc(cc1)C(OCCN2CCN(CCCc3ccccc3)CC2)c4ccc(F)cc4

InChI

1S/C28H32F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-3,5-6,8-15,28H,4,7,16-22H2;2*1H

InChI key

MIBSKSYCRFWIRU-UHFFFAOYSA-N

Gene Information

human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)

说明

Application

GBR 12909二盐酸盐可作为多巴胺转运体(DAT)抑制剂，用于：

研究其对小鼠纹状体中脂多糖(LPS)诱导的促炎性细胞因子mRNA表达的影响
研究其对斑马鱼大脑神经递质释放的影响
小鼠纹状体的多巴胺摄取试验

Biochem/physiol Actions

GBR 12909可作为药物治疗可卡因上瘾。

GBR 12909是一种具有类似可卡因行为效应的高度选择性多巴胺再摄取抑制剂。

Features and Benefits

该化合物收录于受体分类和信号转导手册的《生物胺转运体》页面。想要浏览手册的其他页面，请单击此处。

Still not finding the right product?

Explore all of our products under GBR 12909 二盐酸盐

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Assessment of receptor occupancy-over-time of two dopamine transporter inhibitors by [(11)C]CIT and target controlled infusion.

Olof Eriksson et al.

Upsala journal of medical sciences, 116(2), 100-106 (2011-03-30)

Occupancy-over-time was determined for two dopamine transporter (DAT) inhibitors through modeling of their ability to displace the PET ligand [(11)C]CIT. The tracer was held at a pseudo steady state in a reference tissue by target controlled infusion. Rhesus monkeys (n

Modulation of high impulsivity and attentional performance in rats by selective direct and indirect dopaminergic and noradrenergic receptor agonists.

Anushka B P Fernando et al.

Psychopharmacology, 219(2), 341-352 (2011-07-16)

Impulsivity is associated with a number of psychiatric disorders, most notably attention deficit/hyperactivity disorder (ADHD). Drugs that augment catecholamine function (e.g. methylphenidate and the selective noradrenaline reuptake inhibitor atomoxetine) have clinical efficacy in ADHD, but their precise mechanism of action

Inhibitory control and response latency differences between C57BL/6J and DBA/2J mice in a Go/No-Go and 5-choice serial reaction time task and strain-specific responsivity to amphetamine.

Maarten Loos et al.

Behavioural brain research, 214(2), 216-224 (2010-06-29)

Among the best-replicated and most heritable endophenotypes of attention-deficit/hyperactivity disorder (ADHD) are deficits in attention, inhibitory response control and larger intra-individual variability in response latencies. Here, we explored the presence of these heritable ADHD endophenotypes in two commonly used inbred

查看所有相关文献

全球贸易项目编号

货号	GTIN
D052-100MG	04061833557754
D052-250MG	04061833557761
D052-25MG	04061833557778