D054
R（+）-SCH-23390 盐酸盐
≥98% (HPLC), dopamine receptor antagonist, solid
别名:
R（+）-7-氯-8-羟基-3-甲基-1-苯基-2，3，4，5-四氢-1H-3-苯并氮杂 盐酸盐
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关于此项目
经验公式（希尔记法）:
C17H18ClNO · HCl
化学文摘社编号:
分子量:
324.24
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
R（+）-SCH-23390 盐酸盐, ≥98% (HPLC), solid
Quality Level
assay
≥98% (HPLC)
form
solid
optical activity
[α]/D +32.1°, c = 1 in DMF(lit.)
storage condition
desiccated, protect from light
color
white
solubility
H2O: >5 mg/mL
SMILES string
Cl[H].CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c3ccccc3
InChI
1S/C17H18ClNO.ClH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H/t15-;/m1./s1
InChI key
OYCAEWMSOPMASE-XFULWGLBSA-N
Gene Information
human ... DRD1(1812)
Application
R(+)-SCH-23390盐酸盐可用于：
- 腹腔注射实验大鼠，研究D1受体在致敏性中的作用
- 作为D1受体选择性拮抗剂，注入颅内药物
- 作为D1受体拮抗剂，研究其对鱼类学习能力的影响
Biochem/physiol Actions
R(+)-SCH-23390盐酸盐是一种选择性D1多巴胺受体拮抗剂。在体外对5-羟色胺2 (5-HT2)和5-HT1C 血清素受体亚型具有更强的结合力。给药后R(+)-SCH-23390的半衰期为25分钟。众所周知，它具有抗定型和促僵硬作用。此外，它还对肌动活动有抑制作用。
Legal Information
经先灵葆雅许可出售。
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
SCH 23390: the first selective dopamine D1-like receptor antagonist
Bourne James A
Cns Drug Reviews, 7(4), 399-414 (2001)
A Sidhu et al.
European journal of pharmacology, 128(3), 213-220 (1986-09-09)
[125I]SCH 23982, [125I]8-iodo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol, binds reversibly and with high affinity (Kd = 0.7 +/- 0.05 nM) to specific binding sites (maximum binding = 108 +/- 3.5 fmol/mg) in the caudate nucleus of the rat brain. The caudate binding site displays pharmacological
Rewarding properties of methylphenidate: sensitization by prior exposure to the drug and effects of dopamine D1-and D2-receptor antagonists
Meririnne E, et al.
Journal of Pharmacology and Experimental Therapeutics, 298(2), 539-550 (2001)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D054-25MG | 04061833557815 |
| D054-5MG | 04061833557822 |
| D054-100MG | 04061832090108 |
| D054-10MG | 04061833557808 |