产品名称
DNQX, ≥98% (TLC)
Quality Level
assay
≥98% (TLC)
form
powder
SMILES string
[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1[N+]([O-])=O
InChI
1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)
InChI key
RWVIMCIPOAXUDG-UHFFFAOYSA-N
Gene Information
human ... GRIA1(2890), GRIA2(2891), GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIK5(2901)
mouse ... Gria1(14799)
rat ... Gria1(50592), Grik1(29559), Grik4(24406), Grin2a(24409)
Application
在各种实验中,DNQX 已被用于阻断 N-甲基-D-天冬氨酸 (NMDA) 和 α-氨基-3-羟基-5-甲基-4-异恶唑丙酸(AMPA) 受体。
Biochem/physiol Actions
DNQX是一种喹喔啉衍生物。
一种竞争性红藻氨酸,使君子氨酸(非NMDA)谷氨酸受体拮抗剂。
Features and Benefits
该化合物是受体分类及信号转导手册上谷氨酸受体(离子通道家族)页面上的特色化合物。想要浏览手册的其他页面, 请单击此处。
这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
商品
DISCOVER Bioactive Small Molecules for Neuroscience
J Waider et al.
Translational psychiatry, 7(10), e1246-e1246 (2017-10-04)
Multiple lines of evidence implicate brain serotonin (5-hydroxytryptamine; 5-HT) system dysfunction in the pathophysiology of stressor-related and anxiety disorders. Here we investigate the influence of constitutively deficient 5-HT synthesis on stressor-related anxiety-like behaviors using Tryptophan hydroxylase 2 (Tph2) mutant mice.
Differential Desensitization Observed at Multiple Effectors of Somatic mu-Opioid Receptors Underlies Sustained Agonist-Mediated Inhibition of Proopiomelanocortin Neuron Activity
Fox PD and Hentges ST
The Journal of Neuroscience, 37(36), 8667-8677 (2017)
Chuanqiang Zhang et al.
BMC biology, 17(1), 95-95 (2019-11-30)
Optogenetic silencing techniques have expanded the causal understanding of the functions of diverse neuronal cell types in both the healthy and diseased brain. A widely used inhibitory optogenetic actuator is eNpHR3.0, an improved version of the light-driven chloride pump halorhodopsin
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D0540-25MG | 04061832090146 |
| D0540-50MG | 04061833557839 |