D0564
Diphtheria Toxin
from Corynebacterium diphtheriae, ≥98% (SDS-PAGE), lyophilized powder, protein synthesis inhibitor
别名:
DTx
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关于此项目
Form:
lyophilized powder
Quality level:
产品名称
白喉毒素 来源于白喉杆菌, lyophilized powder, Product is in unnicked form
Quality Level
form
lyophilized powder
storage temp.
2-8°C
General description
白喉毒素可用作细胞特异性细胞毒性免疫毒素中的毒素成分。具有天然内体逃逸机制的细菌毒素易位结构域已被用于开发有效的非病毒载体用于基因治疗。
Application
白喉棒状杆菌的白喉毒素已用于：
- 小胶质细胞耗竭，研究小鼠创伤后应激障碍
- 腹腔注射转基因小鼠，以在消融过程中融合移植的造血干细胞和祖细胞（HSPCs）后选择杂交种
- 研究其对嗜酸性粒细胞缺陷小鼠株（iPHIL）中嗜酸性粒细胞系祖细胞的影响
Biochem/physiol Actions
白喉毒素是一种由白喉棒状杆菌产生的细菌毒素。它包含三个具有细胞内作用的结构域。这些结构域参与细胞中毒、细胞表面结合和内化为内体、穿过内体膜转运到胞质溶胶并抑制细胞蛋白质合成。白喉毒素可用于构建生物技术工具和治疗方法。它通过催化真核生物中靶蛋白的二磷酸腺苷（ADP）核糖基化来抑制蛋白质合成。
Physical form
含Tris和EDTA的冻干粉。
Preparation Note
当用无菌蒸馏水将每管重悬至0.5 mL时，0.01 M Tris和0.001 M Na2EDTA，pH 7.5中含有~1 mg的白喉毒素。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 1 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
高风险级别生物产品--毒素类产品
此项目有
S M Yellon et al.
Biology of reproduction, 100(5), 1386-1394 (2019-01-11)
To test the hypothesis that macrophages are essential for remodeling the cervix in preparation for birth, pregnant homozygous CD11b-dtr mice were injected with diphtheria toxin (DT) on days 14 and 16 postbreeding. On day 15 postbreeding, macrophages (F4/80+) were depleted
Biology and molecular epidemiology of diphtheria toxin and the tox gene
The Journal of Infectious Diseases, 181 (2000)
Nicole Schmitner et al.
Disease models & mechanisms, 10(3), 307-321 (2017-02-01)
The exocrine pancreas displays a significant capacity for regeneration and renewal. In humans and mammalian model systems, the partial loss of exocrine tissue, such as after acute pancreatitis or partial pancreatectomy induces rapid recovery via expansion of surviving acinar cells.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D0564-1MG | 04061833557860 |